Cargando…

Effects of Neonatal Fluvoxamine Administration on the Physical Development and Activity of the Serotoninergic System in White Rats

Selective serotonin reuptake inhibitors (SSRIs), including fluvoxamine, are widely used to treat depressive disorders in pregnant women. These antidepressants effectively penetrate through the placental barrier, affecting the fetus during the critical phase of neurodevelopment. Some clinical studies...

Descripción completa

Detalles Bibliográficos
Autores principales: Glazova, N. Yu., Merchieva, S. A., Volodina, M. A., Sebentsova, E. A., Manchenko, D. M., Kudrun, V. S., Levitskaya, N. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207564/
https://www.ncbi.nlm.nih.gov/pubmed/25349718
_version_ 1782340991441698816
author Glazova, N. Yu.
Merchieva, S. A.
Volodina, M. A.
Sebentsova, E. A.
Manchenko, D. M.
Kudrun, V. S.
Levitskaya, N. G.
author_facet Glazova, N. Yu.
Merchieva, S. A.
Volodina, M. A.
Sebentsova, E. A.
Manchenko, D. M.
Kudrun, V. S.
Levitskaya, N. G.
author_sort Glazova, N. Yu.
collection PubMed
description Selective serotonin reuptake inhibitors (SSRIs), including fluvoxamine, are widely used to treat depressive disorders in pregnant women. These antidepressants effectively penetrate through the placental barrier, affecting the fetus during the critical phase of neurodevelopment. Some clinical studies have linked prenatal exposure to SSRIs with increased neonatal mortality, premature birth, decreased fetal growth and delay in psychomotor development. However, the effects of prenatal exposure to SSRIs remain unknown. The administration of SSRIs in rodents during the first postnatal weeks is considered as an model for studying the effects of prenatal SSRIs exposure in human. The aim of this work was to study the acute effects of chronic fluvoxamine (FA) administration in white rat pups. The study was carried out in male and female rat pups treated with FA (10 mg/kg/day, intraperitoneally) from postnatal days 1 to 14. The lethality level, body weight, age of eye opening, and motor reflex maturation were recorded. The contents of biogenic amines and their metabolites in different brain structures were also determined. It was shown that neonatal FA administration led to increased lethality level, reduced body weight, and delayed maturation of motor reflexes. Furthermore, increased noradrenalin level in hypothalamus, serotonin level in hippocampus and serotonin metabolite 5-HIAA level in frontal cortex, hypothalamus, hippocampus, and striatum were observed in drug-treated animals compared to the control group. We can conclude that the altered activity of the serotoninergic system induced by fluvoxamine administration at early developmental stages leads to a delay in physical and motor development.
format Online
Article
Text
id pubmed-4207564
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher A.I. Gordeyev
record_format MEDLINE/PubMed
spelling pubmed-42075642014-10-27 Effects of Neonatal Fluvoxamine Administration on the Physical Development and Activity of the Serotoninergic System in White Rats Glazova, N. Yu. Merchieva, S. A. Volodina, M. A. Sebentsova, E. A. Manchenko, D. M. Kudrun, V. S. Levitskaya, N. G. Acta Naturae Research Article Selective serotonin reuptake inhibitors (SSRIs), including fluvoxamine, are widely used to treat depressive disorders in pregnant women. These antidepressants effectively penetrate through the placental barrier, affecting the fetus during the critical phase of neurodevelopment. Some clinical studies have linked prenatal exposure to SSRIs with increased neonatal mortality, premature birth, decreased fetal growth and delay in psychomotor development. However, the effects of prenatal exposure to SSRIs remain unknown. The administration of SSRIs in rodents during the first postnatal weeks is considered as an model for studying the effects of prenatal SSRIs exposure in human. The aim of this work was to study the acute effects of chronic fluvoxamine (FA) administration in white rat pups. The study was carried out in male and female rat pups treated with FA (10 mg/kg/day, intraperitoneally) from postnatal days 1 to 14. The lethality level, body weight, age of eye opening, and motor reflex maturation were recorded. The contents of biogenic amines and their metabolites in different brain structures were also determined. It was shown that neonatal FA administration led to increased lethality level, reduced body weight, and delayed maturation of motor reflexes. Furthermore, increased noradrenalin level in hypothalamus, serotonin level in hippocampus and serotonin metabolite 5-HIAA level in frontal cortex, hypothalamus, hippocampus, and striatum were observed in drug-treated animals compared to the control group. We can conclude that the altered activity of the serotoninergic system induced by fluvoxamine administration at early developmental stages leads to a delay in physical and motor development. A.I. Gordeyev 2014 /pmc/articles/PMC4207564/ /pubmed/25349718 Text en Copyright ® 2014 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Glazova, N. Yu.
Merchieva, S. A.
Volodina, M. A.
Sebentsova, E. A.
Manchenko, D. M.
Kudrun, V. S.
Levitskaya, N. G.
Effects of Neonatal Fluvoxamine Administration on the Physical Development and Activity of the Serotoninergic System in White Rats
title Effects of Neonatal Fluvoxamine Administration on the Physical Development and Activity of the Serotoninergic System in White Rats
title_full Effects of Neonatal Fluvoxamine Administration on the Physical Development and Activity of the Serotoninergic System in White Rats
title_fullStr Effects of Neonatal Fluvoxamine Administration on the Physical Development and Activity of the Serotoninergic System in White Rats
title_full_unstemmed Effects of Neonatal Fluvoxamine Administration on the Physical Development and Activity of the Serotoninergic System in White Rats
title_short Effects of Neonatal Fluvoxamine Administration on the Physical Development and Activity of the Serotoninergic System in White Rats
title_sort effects of neonatal fluvoxamine administration on the physical development and activity of the serotoninergic system in white rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207564/
https://www.ncbi.nlm.nih.gov/pubmed/25349718
work_keys_str_mv AT glazovanyu effectsofneonatalfluvoxamineadministrationonthephysicaldevelopmentandactivityoftheserotoninergicsysteminwhiterats
AT merchievasa effectsofneonatalfluvoxamineadministrationonthephysicaldevelopmentandactivityoftheserotoninergicsysteminwhiterats
AT volodinama effectsofneonatalfluvoxamineadministrationonthephysicaldevelopmentandactivityoftheserotoninergicsysteminwhiterats
AT sebentsovaea effectsofneonatalfluvoxamineadministrationonthephysicaldevelopmentandactivityoftheserotoninergicsysteminwhiterats
AT manchenkodm effectsofneonatalfluvoxamineadministrationonthephysicaldevelopmentandactivityoftheserotoninergicsysteminwhiterats
AT kudrunvs effectsofneonatalfluvoxamineadministrationonthephysicaldevelopmentandactivityoftheserotoninergicsysteminwhiterats
AT levitskayang effectsofneonatalfluvoxamineadministrationonthephysicaldevelopmentandactivityoftheserotoninergicsysteminwhiterats