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Angora Wool Asthma in Textile Industry

Up to now the exposures to hair and skin derivatives of animals have not yet been the subject of systematic studies. The observation of a clinical case has provided the opportunity for a review of the literature. The inpatient was a 49-year-old man, a carder in a textile factory, exposed to angora w...

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Autores principales: Sartorelli, Pietro, Romeo, Riccardo, Coppola, Giuseppina, Nuti, Roberta, Paolucci, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207589/
https://www.ncbi.nlm.nih.gov/pubmed/25379305
http://dx.doi.org/10.1155/2012/358271
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author Sartorelli, Pietro
Romeo, Riccardo
Coppola, Giuseppina
Nuti, Roberta
Paolucci, Valentina
author_facet Sartorelli, Pietro
Romeo, Riccardo
Coppola, Giuseppina
Nuti, Roberta
Paolucci, Valentina
author_sort Sartorelli, Pietro
collection PubMed
description Up to now the exposures to hair and skin derivatives of animals have not yet been the subject of systematic studies. The observation of a clinical case has provided the opportunity for a review of the literature. The inpatient was a 49-year-old man, a carder in a textile factory, exposed to angora wool. He noticed the appearance of dyspnea during working hours. There was no eosinophilia in blood, and the results of pulmonary function tests were normal. The nonspecific bronchial provocation test with methacholine demonstrated an abnormal bronchial reactivity. The challenge test with angora wool was positive (decrease in FEV1 of more than 40%) as well as total IGE and specific IgE to rabbit epithelium (433 KU/l and 12.1 KUA/l, resp.). Several sources of allergens were found in the rabbit, and the main allergen was represented by proteins from epithelia, urine, and saliva. Most of these proteins belong to the family of lipocalin, they function as carriers for small hydrophobic molecules (vitamins and pheromones). If the diagnosis of occupational asthma caused by animal hair and skin derivatives may be relatively easy by means of the challenge test, defining etiology is complicated because of the lack of in vitro tests.
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spelling pubmed-42075892014-11-06 Angora Wool Asthma in Textile Industry Sartorelli, Pietro Romeo, Riccardo Coppola, Giuseppina Nuti, Roberta Paolucci, Valentina Case Reports Immunol Case Report Up to now the exposures to hair and skin derivatives of animals have not yet been the subject of systematic studies. The observation of a clinical case has provided the opportunity for a review of the literature. The inpatient was a 49-year-old man, a carder in a textile factory, exposed to angora wool. He noticed the appearance of dyspnea during working hours. There was no eosinophilia in blood, and the results of pulmonary function tests were normal. The nonspecific bronchial provocation test with methacholine demonstrated an abnormal bronchial reactivity. The challenge test with angora wool was positive (decrease in FEV1 of more than 40%) as well as total IGE and specific IgE to rabbit epithelium (433 KU/l and 12.1 KUA/l, resp.). Several sources of allergens were found in the rabbit, and the main allergen was represented by proteins from epithelia, urine, and saliva. Most of these proteins belong to the family of lipocalin, they function as carriers for small hydrophobic molecules (vitamins and pheromones). If the diagnosis of occupational asthma caused by animal hair and skin derivatives may be relatively easy by means of the challenge test, defining etiology is complicated because of the lack of in vitro tests. Hindawi Publishing Corporation 2012 2012-09-23 /pmc/articles/PMC4207589/ /pubmed/25379305 http://dx.doi.org/10.1155/2012/358271 Text en Copyright © 2012 Pietro Sartorelli et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Sartorelli, Pietro
Romeo, Riccardo
Coppola, Giuseppina
Nuti, Roberta
Paolucci, Valentina
Angora Wool Asthma in Textile Industry
title Angora Wool Asthma in Textile Industry
title_full Angora Wool Asthma in Textile Industry
title_fullStr Angora Wool Asthma in Textile Industry
title_full_unstemmed Angora Wool Asthma in Textile Industry
title_short Angora Wool Asthma in Textile Industry
title_sort angora wool asthma in textile industry
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207589/
https://www.ncbi.nlm.nih.gov/pubmed/25379305
http://dx.doi.org/10.1155/2012/358271
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AT paoluccivalentina angorawoolasthmaintextileindustry