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P. vivax Malaria and Dengue Fever Co-infection: A Cross-Sectional Study in the Brazilian Amazon
BACKGROUND: Malaria and dengue are the most prevalent vector-borne diseases worldwide and represent major public health problems. Both are endemic in tropical regions, propitiating co-infection. Only few co-infection cases have been reported around the world, with insufficient data so far to enhance...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207662/ https://www.ncbi.nlm.nih.gov/pubmed/25340346 http://dx.doi.org/10.1371/journal.pntd.0003239 |
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author | Magalhães, Belisa M. L. Siqueira, André M. Alexandre, Márcia A. A. Souza, Marcela S. Gimaque, João B. Bastos, Michele S. Figueiredo, Regina M. P. Melo, Gisely C. Lacerda, Marcus V. G. Mourão, Maria P. G. |
author_facet | Magalhães, Belisa M. L. Siqueira, André M. Alexandre, Márcia A. A. Souza, Marcela S. Gimaque, João B. Bastos, Michele S. Figueiredo, Regina M. P. Melo, Gisely C. Lacerda, Marcus V. G. Mourão, Maria P. G. |
author_sort | Magalhães, Belisa M. L. |
collection | PubMed |
description | BACKGROUND: Malaria and dengue are the most prevalent vector-borne diseases worldwide and represent major public health problems. Both are endemic in tropical regions, propitiating co-infection. Only few co-infection cases have been reported around the world, with insufficient data so far to enhance the understanding of the effects of co-infection in the clinical presentation and severity. METHODOLOGY/PRINCIPAL FINDINGS: A cross-sectional study was conducted (2009 to 2011) in hospitalized patients with acute febrile syndrome in the Brazilian Amazon. All patients were submitted to thick blood smear and PCR for Plasmodium sp. detection, ELISA, PCR and NS1 tests for dengue, viral hepatitis, HIV and leptospirosis. In total, 1,578 patients were recruited. Among them, 176 (11.1%) presented P. vivax malaria mono-infection, 584 (37%) dengue fever mono-infection, and 44 (2.8%) were co-infected. Co-infected patients had a higher chance of presenting severe disease (vs. dengue mono-infected), deep bleeding (vs. P. vivax mono-infected), hepatomegaly, and jaundice (vs. dengue mono-infected). CONCLUSIONS/SIGNIFICANCE: In endemic areas for dengue and malaria, jaundice (in dengue patients) and spontaneous bleeding (in malaria patients) should raise the suspicion of co-infection. Besides, whenever co-infection is confirmed, we recommend careful monitoring for bleeding and hepatic complications, which may result in a higher chance of severity, despite of the fact that no increased fatality rate was seen in this group. |
format | Online Article Text |
id | pubmed-4207662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-42076622014-10-27 P. vivax Malaria and Dengue Fever Co-infection: A Cross-Sectional Study in the Brazilian Amazon Magalhães, Belisa M. L. Siqueira, André M. Alexandre, Márcia A. A. Souza, Marcela S. Gimaque, João B. Bastos, Michele S. Figueiredo, Regina M. P. Melo, Gisely C. Lacerda, Marcus V. G. Mourão, Maria P. G. PLoS Negl Trop Dis Research Article BACKGROUND: Malaria and dengue are the most prevalent vector-borne diseases worldwide and represent major public health problems. Both are endemic in tropical regions, propitiating co-infection. Only few co-infection cases have been reported around the world, with insufficient data so far to enhance the understanding of the effects of co-infection in the clinical presentation and severity. METHODOLOGY/PRINCIPAL FINDINGS: A cross-sectional study was conducted (2009 to 2011) in hospitalized patients with acute febrile syndrome in the Brazilian Amazon. All patients were submitted to thick blood smear and PCR for Plasmodium sp. detection, ELISA, PCR and NS1 tests for dengue, viral hepatitis, HIV and leptospirosis. In total, 1,578 patients were recruited. Among them, 176 (11.1%) presented P. vivax malaria mono-infection, 584 (37%) dengue fever mono-infection, and 44 (2.8%) were co-infected. Co-infected patients had a higher chance of presenting severe disease (vs. dengue mono-infected), deep bleeding (vs. P. vivax mono-infected), hepatomegaly, and jaundice (vs. dengue mono-infected). CONCLUSIONS/SIGNIFICANCE: In endemic areas for dengue and malaria, jaundice (in dengue patients) and spontaneous bleeding (in malaria patients) should raise the suspicion of co-infection. Besides, whenever co-infection is confirmed, we recommend careful monitoring for bleeding and hepatic complications, which may result in a higher chance of severity, despite of the fact that no increased fatality rate was seen in this group. Public Library of Science 2014-10-23 /pmc/articles/PMC4207662/ /pubmed/25340346 http://dx.doi.org/10.1371/journal.pntd.0003239 Text en © 2014 Magalhães et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Magalhães, Belisa M. L. Siqueira, André M. Alexandre, Márcia A. A. Souza, Marcela S. Gimaque, João B. Bastos, Michele S. Figueiredo, Regina M. P. Melo, Gisely C. Lacerda, Marcus V. G. Mourão, Maria P. G. P. vivax Malaria and Dengue Fever Co-infection: A Cross-Sectional Study in the Brazilian Amazon |
title |
P. vivax Malaria and Dengue Fever Co-infection: A Cross-Sectional Study in the Brazilian Amazon |
title_full |
P. vivax Malaria and Dengue Fever Co-infection: A Cross-Sectional Study in the Brazilian Amazon |
title_fullStr |
P. vivax Malaria and Dengue Fever Co-infection: A Cross-Sectional Study in the Brazilian Amazon |
title_full_unstemmed |
P. vivax Malaria and Dengue Fever Co-infection: A Cross-Sectional Study in the Brazilian Amazon |
title_short |
P. vivax Malaria and Dengue Fever Co-infection: A Cross-Sectional Study in the Brazilian Amazon |
title_sort | p. vivax malaria and dengue fever co-infection: a cross-sectional study in the brazilian amazon |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207662/ https://www.ncbi.nlm.nih.gov/pubmed/25340346 http://dx.doi.org/10.1371/journal.pntd.0003239 |
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