Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation

Cerebrospinal fluid (CSF) 42 amino acid species of amyloid beta (Aβ42) and tau levels are strongly correlated with the presence of Alzheimer's disease (AD) neuropathology including amyloid plaques and neurodegeneration and have been successfully used as endophenotypes for genetic studies of AD....

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Detalles Bibliográficos
Autores principales: Kauwe, John S. K., Bailey, Matthew H., Ridge, Perry G., Perry, Rachel, Wadsworth, Mark E., Hoyt, Kaitlyn L., Staley, Lyndsay A., Karch, Celeste M., Harari, Oscar, Cruchaga, Carlos, Ainscough, Benjamin J., Bales, Kelly, Pickering, Eve H., Bertelsen, Sarah, Fagan, Anne M., Holtzman, David M., Morris, John C., Goate, Alison M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207667/
https://www.ncbi.nlm.nih.gov/pubmed/25340798
http://dx.doi.org/10.1371/journal.pgen.1004758

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