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A Polyketide Synthase Acyltransferase Domain Structure Suggests a Recognition Mechanism for Its Hydroxymalonyl-Acyl Carrier Protein Substrate

We have previously shown that the acyl transferase domain of ZmaA (ZmaA-AT) is involved in the biosynthesis of the aminopolyol polyketide/nonribosomal peptide hybrid molecule zwittermicin A from cereus UW85, and that it specifically recognizes the precursor hydroxymalonyl-acyl carrier protein (ACP)...

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Detalles Bibliográficos
Autores principales:	Park, Hyunjun, Kevany, Brian M., Dyer, David H., Thomas, Michael G., Forest, Katrina T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207774/ https://www.ncbi.nlm.nih.gov/pubmed/25340352 http://dx.doi.org/10.1371/journal.pone.0110965

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