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Time-dependent activation of MAPK/Erk1/2 and Akt/GSK3 cascades: modulation by agomelatine

BACKGROUND: The novel antidepressant agomelatine, a melatonergic MT(1)/MT(2) agonist combined with 5-HT(2c) serotonin antagonist properties, showed antidepressant action in preclinical and clinical studies. There is a general agreement that the therapeutic action of antidepressants needs the activat...

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Detalles Bibliográficos
Autores principales:	Musazzi, Laura, Seguini, Mara, Mallei, Alessandra, Treccani, Giulia, Pelizzari, Mariagrazia, Tornese, Paolo, Racagni, Giorgio, Tardito, Daniela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207903/ https://www.ncbi.nlm.nih.gov/pubmed/25332063 http://dx.doi.org/10.1186/s12868-014-0119-1

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