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Follow-up of children with hemoglobinopathies diagnosed by the Brazilian Neonatal Screening Program in the State of Pernambuco

OBJECTIVE: To determine the geographical distribution of hemoglobinopathies in the State of Pernambuco, to characterize the children with these diseases and to describe factors associated with their follow-up at the referral center during the period from 2003 to 2010. METHODS: A retrospective, cross...

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Autores principales: Soares, Ana Caroline Novaes, Samico, Isabella Chagas, Araújo, Aderson Silva, Bezerra, Marcos André C., Hatzlhofer, Betânia Lucena Domingues
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Hematologia e Hemoterapia 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207915/
https://www.ncbi.nlm.nih.gov/pubmed/25031163
http://dx.doi.org/10.1016/j.bjhh.2014.05.001
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author Soares, Ana Caroline Novaes
Samico, Isabella Chagas
Araújo, Aderson Silva
Bezerra, Marcos André C.
Hatzlhofer, Betânia Lucena Domingues
author_facet Soares, Ana Caroline Novaes
Samico, Isabella Chagas
Araújo, Aderson Silva
Bezerra, Marcos André C.
Hatzlhofer, Betânia Lucena Domingues
author_sort Soares, Ana Caroline Novaes
collection PubMed
description OBJECTIVE: To determine the geographical distribution of hemoglobinopathies in the State of Pernambuco, to characterize the children with these diseases and to describe factors associated with their follow-up at the referral center during the period from 2003 to 2010. METHODS: A retrospective, cross-sectional, descriptive study was carried out of 275 medical records from a total of 302 children with hemoglobinopathies diagnosed by the National Neonatal Screening Program in the State of Pernambuco in the study period. Microsoft Excel was used for data processing and analysis. The chi-square and the Fisher test were used for statistical analysis. The level of significance was set at 5%. Terra View software was used to analyze the geographical distribution of hemoglobinopathies in the State. RESULTS: A total of 8.9% of the cases of hemoglobinopathies detected in the period were not followed up at the referral center. For the mothers of children with diseases, this was their second or third or more pregnancy in 64.2% and 30.2%, respectively. Regarding the influence of region of residence and regular medical appointments, the study demonstrated that children from the Zona da Mata, Sertão and Vale do São Francisco regions did not attend 45.2%, 50% and 55.6% of their appointments in the outpatient department, respectively. CONCLUSIONS: This study shows that a significant number of children do not begin consultations in the outpatient clinic and even those who started treatment early and who have the most severe form of the disease, usually miss medical appointments.
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spelling pubmed-42079152014-10-27 Follow-up of children with hemoglobinopathies diagnosed by the Brazilian Neonatal Screening Program in the State of Pernambuco Soares, Ana Caroline Novaes Samico, Isabella Chagas Araújo, Aderson Silva Bezerra, Marcos André C. Hatzlhofer, Betânia Lucena Domingues Rev Bras Hematol Hemoter Original Article OBJECTIVE: To determine the geographical distribution of hemoglobinopathies in the State of Pernambuco, to characterize the children with these diseases and to describe factors associated with their follow-up at the referral center during the period from 2003 to 2010. METHODS: A retrospective, cross-sectional, descriptive study was carried out of 275 medical records from a total of 302 children with hemoglobinopathies diagnosed by the National Neonatal Screening Program in the State of Pernambuco in the study period. Microsoft Excel was used for data processing and analysis. The chi-square and the Fisher test were used for statistical analysis. The level of significance was set at 5%. Terra View software was used to analyze the geographical distribution of hemoglobinopathies in the State. RESULTS: A total of 8.9% of the cases of hemoglobinopathies detected in the period were not followed up at the referral center. For the mothers of children with diseases, this was their second or third or more pregnancy in 64.2% and 30.2%, respectively. Regarding the influence of region of residence and regular medical appointments, the study demonstrated that children from the Zona da Mata, Sertão and Vale do São Francisco regions did not attend 45.2%, 50% and 55.6% of their appointments in the outpatient department, respectively. CONCLUSIONS: This study shows that a significant number of children do not begin consultations in the outpatient clinic and even those who started treatment early and who have the most severe form of the disease, usually miss medical appointments. Sociedade Brasileira de Hematologia e Hemoterapia 2014 2014-05-27 /pmc/articles/PMC4207915/ /pubmed/25031163 http://dx.doi.org/10.1016/j.bjhh.2014.05.001 Text en © 2014 Associaç˜ao Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Original Article
Soares, Ana Caroline Novaes
Samico, Isabella Chagas
Araújo, Aderson Silva
Bezerra, Marcos André C.
Hatzlhofer, Betânia Lucena Domingues
Follow-up of children with hemoglobinopathies diagnosed by the Brazilian Neonatal Screening Program in the State of Pernambuco
title Follow-up of children with hemoglobinopathies diagnosed by the Brazilian Neonatal Screening Program in the State of Pernambuco
title_full Follow-up of children with hemoglobinopathies diagnosed by the Brazilian Neonatal Screening Program in the State of Pernambuco
title_fullStr Follow-up of children with hemoglobinopathies diagnosed by the Brazilian Neonatal Screening Program in the State of Pernambuco
title_full_unstemmed Follow-up of children with hemoglobinopathies diagnosed by the Brazilian Neonatal Screening Program in the State of Pernambuco
title_short Follow-up of children with hemoglobinopathies diagnosed by the Brazilian Neonatal Screening Program in the State of Pernambuco
title_sort follow-up of children with hemoglobinopathies diagnosed by the brazilian neonatal screening program in the state of pernambuco
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207915/
https://www.ncbi.nlm.nih.gov/pubmed/25031163
http://dx.doi.org/10.1016/j.bjhh.2014.05.001
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