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Transfusion-transmitted malaria in endemic zone: epidemiological profile of blood donors at the Fundação HEMOAM and use of rapid diagnostic tests for malaria screening in Manaus
OBJECTIVE: With 99% of the cases in Brazil, malaria is endemic in the Amazon region. Transfusion-transmitted malaria, an important risk in endemic areas, has been reported. The aim of this study was to describe the epidemiological profile of blood donor candidates at the Fundação de Hematologia e He...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Sociedade Brasileira de Hematologia e Hemoterapia
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207922/ https://www.ncbi.nlm.nih.gov/pubmed/25031166 http://dx.doi.org/10.1016/j.bjhh.2014.05.002 |
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author | Torres, Kátia Luz dos Santos Moresco, Mônica Nascimento Sales, Luciane Rodrigues da Silva Abranches, Josilene Araújo Alexandre, Márcia Almeida Malheiro, Adriana |
author_facet | Torres, Kátia Luz dos Santos Moresco, Mônica Nascimento Sales, Luciane Rodrigues da Silva Abranches, Josilene Araújo Alexandre, Márcia Almeida Malheiro, Adriana |
author_sort | Torres, Kátia Luz |
collection | PubMed |
description | OBJECTIVE: With 99% of the cases in Brazil, malaria is endemic in the Amazon region. Transfusion-transmitted malaria, an important risk in endemic areas, has been reported. The aim of this study was to describe the epidemiological profile of blood donor candidates at the Fundação de Hematologia e Hemoterapia do Amazonas and evaluate the efficacy of rapid diagnostic tests used for malaria screening of blood donors within endemic regions. METHODS: Between May 2008 and May 2009, 407 blood donor candidates were selected and grouped based on the Malaria Annual Parasite Index of the geographic area in which they originated: Group 1 (eligible donors – n = 265) originated from areas of low to medium risk of exposure to malaria and Group 2 (ineligible donors – n = 142) originated from high-risk areas. All samples were concurrently screened using two immunochromatic antigen-based rapid tests and by the thick smear test. RESULTS: All samples were negative by all three methods. The demographic profile indicated that the majority of participants were male, ages ranged from 18 to 39 years and less than half the candidates had only elementary schooling. Two issues need to be addressed: one is the ineligibility of donors and its impact on blood donor centers as, in this study, 22.7% of the donors were considered ineligible. The other is the limited sensitivity of the parasitological tests used, allowing a risk of false-negative results. CONCLUSION: New methods are needed to ensure transfusion safety without rejecting potential donors, which would ensure safe transfusion without harming the blood supply. |
format | Online Article Text |
id | pubmed-4207922 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Sociedade Brasileira de Hematologia e Hemoterapia |
record_format | MEDLINE/PubMed |
spelling | pubmed-42079222014-10-27 Transfusion-transmitted malaria in endemic zone: epidemiological profile of blood donors at the Fundação HEMOAM and use of rapid diagnostic tests for malaria screening in Manaus Torres, Kátia Luz dos Santos Moresco, Mônica Nascimento Sales, Luciane Rodrigues da Silva Abranches, Josilene Araújo Alexandre, Márcia Almeida Malheiro, Adriana Rev Bras Hematol Hemoter Original Article OBJECTIVE: With 99% of the cases in Brazil, malaria is endemic in the Amazon region. Transfusion-transmitted malaria, an important risk in endemic areas, has been reported. The aim of this study was to describe the epidemiological profile of blood donor candidates at the Fundação de Hematologia e Hemoterapia do Amazonas and evaluate the efficacy of rapid diagnostic tests used for malaria screening of blood donors within endemic regions. METHODS: Between May 2008 and May 2009, 407 blood donor candidates were selected and grouped based on the Malaria Annual Parasite Index of the geographic area in which they originated: Group 1 (eligible donors – n = 265) originated from areas of low to medium risk of exposure to malaria and Group 2 (ineligible donors – n = 142) originated from high-risk areas. All samples were concurrently screened using two immunochromatic antigen-based rapid tests and by the thick smear test. RESULTS: All samples were negative by all three methods. The demographic profile indicated that the majority of participants were male, ages ranged from 18 to 39 years and less than half the candidates had only elementary schooling. Two issues need to be addressed: one is the ineligibility of donors and its impact on blood donor centers as, in this study, 22.7% of the donors were considered ineligible. The other is the limited sensitivity of the parasitological tests used, allowing a risk of false-negative results. CONCLUSION: New methods are needed to ensure transfusion safety without rejecting potential donors, which would ensure safe transfusion without harming the blood supply. Sociedade Brasileira de Hematologia e Hemoterapia 2014 2014-05-27 /pmc/articles/PMC4207922/ /pubmed/25031166 http://dx.doi.org/10.1016/j.bjhh.2014.05.002 Text en © 2014 Associaç˜ao Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
spellingShingle | Original Article Torres, Kátia Luz dos Santos Moresco, Mônica Nascimento Sales, Luciane Rodrigues da Silva Abranches, Josilene Araújo Alexandre, Márcia Almeida Malheiro, Adriana Transfusion-transmitted malaria in endemic zone: epidemiological profile of blood donors at the Fundação HEMOAM and use of rapid diagnostic tests for malaria screening in Manaus |
title | Transfusion-transmitted malaria in endemic zone: epidemiological profile of blood donors at the Fundação HEMOAM and use of rapid diagnostic tests for malaria screening in Manaus |
title_full | Transfusion-transmitted malaria in endemic zone: epidemiological profile of blood donors at the Fundação HEMOAM and use of rapid diagnostic tests for malaria screening in Manaus |
title_fullStr | Transfusion-transmitted malaria in endemic zone: epidemiological profile of blood donors at the Fundação HEMOAM and use of rapid diagnostic tests for malaria screening in Manaus |
title_full_unstemmed | Transfusion-transmitted malaria in endemic zone: epidemiological profile of blood donors at the Fundação HEMOAM and use of rapid diagnostic tests for malaria screening in Manaus |
title_short | Transfusion-transmitted malaria in endemic zone: epidemiological profile of blood donors at the Fundação HEMOAM and use of rapid diagnostic tests for malaria screening in Manaus |
title_sort | transfusion-transmitted malaria in endemic zone: epidemiological profile of blood donors at the fundação hemoam and use of rapid diagnostic tests for malaria screening in manaus |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207922/ https://www.ncbi.nlm.nih.gov/pubmed/25031166 http://dx.doi.org/10.1016/j.bjhh.2014.05.002 |
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