Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations

Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson’s disease. LRRK2 is a multifunctional protein affecting many cellular processes and has been described to bind microtubules. Defective microtubule-based axonal transport is hypothesized to contribute to Par...

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Detalles Bibliográficos
Autores principales: Godena, Vinay K., Brookes-Hocking, Nicholas, Moller, Annekathrin, Shaw, Gary, Oswald, Matthew, Sancho, Rosa M., Miller, Christopher C. J., Whitworth, Alexander J., De Vos, Kurt J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208097/
https://www.ncbi.nlm.nih.gov/pubmed/25316291
http://dx.doi.org/10.1038/ncomms6245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208097/
https://www.ncbi.nlm.nih.gov/pubmed/25316291
http://dx.doi.org/10.1038/ncomms6245

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