Chaperone mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation

Chaperone mediated autophagy (CMA) targets soluble proteins for lysosomal degradation. Here we show that CMA is activated in T cells in response to T cell receptor (TCR) engagement, which induces the expression of the lysosomal CMA receptor, LAMP-2A. In activated T cells, CMA targets the ubiquitin l...

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Detalles Bibliográficos
Autores principales: Valdor, Rut, Mocholi, Enric, Botbol, Yair, Guerrero-Ros, Ignacio, Chandra, Dinesh, Koga, Hiroshi, Gravekamp, Claudia, Cuervo, Ana Maria, Macian, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208273/
https://www.ncbi.nlm.nih.gov/pubmed/25263126
http://dx.doi.org/10.1038/ni.3003

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