A Speculative Role for Stromal Gastrin Signaling in Development and Dissemination of Pancreatic Ductal Adenocarcinoma

The peptide growth factor gastrin and its receptor, the G-protein coupled cholecystokinin receptor type B (CCK(B)R), play an integral role in the growth and progression of pancreatic ductal adenocarcinoma (PDAC). Gastrin immunoreactivity is found in the fetal pancreas but its expression is not detec...

Descripción completa

Detalles Bibliográficos
Autores principales: Matters, Gail L, Clawson, Gary A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208305/
https://www.ncbi.nlm.nih.gov/pubmed/25346875
http://dx.doi.org/10.4172/2165-7092.S4-003
_version_ 1782341109010137088
author Matters, Gail L
Clawson, Gary A
author_facet Matters, Gail L
Clawson, Gary A
author_sort Matters, Gail L
collection PubMed
description The peptide growth factor gastrin and its receptor, the G-protein coupled cholecystokinin receptor type B (CCK(B)R), play an integral role in the growth and progression of pancreatic ductal adenocarcinoma (PDAC). Gastrin immunoreactivity is found in the fetal pancreas but its expression is not detected in normal pancreas after birth, except when it is re-expressed in malignant lesions.
format Online
Article
Text
id pubmed-4208305
institution National Center for Biotechnology Information
language English
publishDate 2013
record_format MEDLINE/PubMed
spelling pubmed-42083052014-10-24 A Speculative Role for Stromal Gastrin Signaling in Development and Dissemination of Pancreatic Ductal Adenocarcinoma Matters, Gail L Clawson, Gary A Pancreat Disord Ther Article The peptide growth factor gastrin and its receptor, the G-protein coupled cholecystokinin receptor type B (CCK(B)R), play an integral role in the growth and progression of pancreatic ductal adenocarcinoma (PDAC). Gastrin immunoreactivity is found in the fetal pancreas but its expression is not detected in normal pancreas after birth, except when it is re-expressed in malignant lesions. 2013-04-07 /pmc/articles/PMC4208305/ /pubmed/25346875 http://dx.doi.org/10.4172/2165-7092.S4-003 Text en Copyright: © 2013 Matters GL, et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Matters, Gail L
Clawson, Gary A
A Speculative Role for Stromal Gastrin Signaling in Development and Dissemination of Pancreatic Ductal Adenocarcinoma
title A Speculative Role for Stromal Gastrin Signaling in Development and Dissemination of Pancreatic Ductal Adenocarcinoma
title_full A Speculative Role for Stromal Gastrin Signaling in Development and Dissemination of Pancreatic Ductal Adenocarcinoma
title_fullStr A Speculative Role for Stromal Gastrin Signaling in Development and Dissemination of Pancreatic Ductal Adenocarcinoma
title_full_unstemmed A Speculative Role for Stromal Gastrin Signaling in Development and Dissemination of Pancreatic Ductal Adenocarcinoma
title_short A Speculative Role for Stromal Gastrin Signaling in Development and Dissemination of Pancreatic Ductal Adenocarcinoma
title_sort speculative role for stromal gastrin signaling in development and dissemination of pancreatic ductal adenocarcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208305/
https://www.ncbi.nlm.nih.gov/pubmed/25346875
http://dx.doi.org/10.4172/2165-7092.S4-003
work_keys_str_mv AT mattersgaill aspeculativeroleforstromalgastrinsignalingindevelopmentanddisseminationofpancreaticductaladenocarcinoma
AT clawsongarya aspeculativeroleforstromalgastrinsignalingindevelopmentanddisseminationofpancreaticductaladenocarcinoma
AT mattersgaill speculativeroleforstromalgastrinsignalingindevelopmentanddisseminationofpancreaticductaladenocarcinoma
AT clawsongarya speculativeroleforstromalgastrinsignalingindevelopmentanddisseminationofpancreaticductaladenocarcinoma

Ejemplares similares