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On improving the use of OCT imaging for detecting glaucomatous damage

AIMS: To describe two approaches for improving the detection of glaucomatous damage seen with optical coherence tomography (OCT). METHODS: The two approaches described were: one, a visual analysis of the high-quality OCT circle scans and two, a comparison of local visual field sensitivity loss to lo...

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Autores principales: Hood, Donald C, Raza, Ali S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208344/
https://www.ncbi.nlm.nih.gov/pubmed/24934219
http://dx.doi.org/10.1136/bjophthalmol-2014-305156
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author Hood, Donald C
Raza, Ali S
author_facet Hood, Donald C
Raza, Ali S
author_sort Hood, Donald C
collection PubMed
description AIMS: To describe two approaches for improving the detection of glaucomatous damage seen with optical coherence tomography (OCT). METHODS: The two approaches described were: one, a visual analysis of the high-quality OCT circle scans and two, a comparison of local visual field sensitivity loss to local OCT retinal ganglion cell plus inner plexiform (RGC+) and retinal nerve fibre layer (RNFL) thinning. OCT images were obtained from glaucoma patients and suspects using a spectral domain OCT machine and commercially available scanning protocols. A high-quality peripapillary circle scan (average of 50), a three-dimensional (3D) scan of the optic disc, and a 3D scan of the macula were obtained. RGC+ and RNFL thickness and probability plots were generated from the 3D scans. RESULTS: A close visual analysis of a high-quality circle scan can help avoid both false positive and false negative errors. Similarly, to avoid these errors, the location of abnormal visual field points should be compared to regions of abnormal RGC+ and RNFL thickness. CONCLUSIONS: To improve the sensitivity and specificity of OCT imaging, high-quality images should be visually scrutinised and topographical information from visual fields and OCT scans combined.
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spelling pubmed-42083442014-11-05 On improving the use of OCT imaging for detecting glaucomatous damage Hood, Donald C Raza, Ali S Br J Ophthalmol Supplement AIMS: To describe two approaches for improving the detection of glaucomatous damage seen with optical coherence tomography (OCT). METHODS: The two approaches described were: one, a visual analysis of the high-quality OCT circle scans and two, a comparison of local visual field sensitivity loss to local OCT retinal ganglion cell plus inner plexiform (RGC+) and retinal nerve fibre layer (RNFL) thinning. OCT images were obtained from glaucoma patients and suspects using a spectral domain OCT machine and commercially available scanning protocols. A high-quality peripapillary circle scan (average of 50), a three-dimensional (3D) scan of the optic disc, and a 3D scan of the macula were obtained. RGC+ and RNFL thickness and probability plots were generated from the 3D scans. RESULTS: A close visual analysis of a high-quality circle scan can help avoid both false positive and false negative errors. Similarly, to avoid these errors, the location of abnormal visual field points should be compared to regions of abnormal RGC+ and RNFL thickness. CONCLUSIONS: To improve the sensitivity and specificity of OCT imaging, high-quality images should be visually scrutinised and topographical information from visual fields and OCT scans combined. BMJ Publishing Group 2014-07 /pmc/articles/PMC4208344/ /pubmed/24934219 http://dx.doi.org/10.1136/bjophthalmol-2014-305156 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Supplement
Hood, Donald C
Raza, Ali S
On improving the use of OCT imaging for detecting glaucomatous damage
title On improving the use of OCT imaging for detecting glaucomatous damage
title_full On improving the use of OCT imaging for detecting glaucomatous damage
title_fullStr On improving the use of OCT imaging for detecting glaucomatous damage
title_full_unstemmed On improving the use of OCT imaging for detecting glaucomatous damage
title_short On improving the use of OCT imaging for detecting glaucomatous damage
title_sort on improving the use of oct imaging for detecting glaucomatous damage
topic Supplement
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208344/
https://www.ncbi.nlm.nih.gov/pubmed/24934219
http://dx.doi.org/10.1136/bjophthalmol-2014-305156
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