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Alterations in the Coagulation System during Major Visceral Surgery in Children
Purpose. The description of the alterations in the hemostatic system in children undergoing abdominal surgery is sparse. Enhanced clinical outcomes for previously untreatable conditions have led to an increased incidence of venous thromboembolic complications. Alterations in children's coagulat...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208503/ https://www.ncbi.nlm.nih.gov/pubmed/25379558 http://dx.doi.org/10.1155/2014/756809 |
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author | Kordjian, Hayarpi H. Nybo, Mads Qvist, Niels |
author_facet | Kordjian, Hayarpi H. Nybo, Mads Qvist, Niels |
author_sort | Kordjian, Hayarpi H. |
collection | PubMed |
description | Purpose. The description of the alterations in the hemostatic system in children undergoing abdominal surgery is sparse. Enhanced clinical outcomes for previously untreatable conditions have led to an increased incidence of venous thromboembolic complications. Alterations in children's coagulation system during major abdominal operations compared to minor procedures were examined. Methods. Children (0–12 years) undergoing either laparotomy, thoracotomy, or minor surgery were included. Participants were divided into two groups: group 1 was open laparotomy including operations for solid abdominal tumours and thoracotomy, while group 2 was minor surgery. Activated partial thromboplastin time (aPTT), D-dimer, INR, and fibrinogen were measured. Results. Both groups had a shorter aPTT, higher INR, and lower fibrinogen concentrations after the operation, while D-dimer was unaltered. The changes were, however, discrete and probably not clinically significant. On day 3, all parameters except aPTT in group 1 (not measured in group 2) indicated a continuous coagulation activity. Conclusion. The tendency for coagulation activity altered based on the length and degree of surgery. A continuously altered activity was observed compatible with the reported increased risk of venous thromboembolism at day 3. However, before introducing thromboprophylaxis guidelines larger series of multicentre studies are needed. |
format | Online Article Text |
id | pubmed-4208503 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-42085032014-11-06 Alterations in the Coagulation System during Major Visceral Surgery in Children Kordjian, Hayarpi H. Nybo, Mads Qvist, Niels Surg Res Pract Research Article Purpose. The description of the alterations in the hemostatic system in children undergoing abdominal surgery is sparse. Enhanced clinical outcomes for previously untreatable conditions have led to an increased incidence of venous thromboembolic complications. Alterations in children's coagulation system during major abdominal operations compared to minor procedures were examined. Methods. Children (0–12 years) undergoing either laparotomy, thoracotomy, or minor surgery were included. Participants were divided into two groups: group 1 was open laparotomy including operations for solid abdominal tumours and thoracotomy, while group 2 was minor surgery. Activated partial thromboplastin time (aPTT), D-dimer, INR, and fibrinogen were measured. Results. Both groups had a shorter aPTT, higher INR, and lower fibrinogen concentrations after the operation, while D-dimer was unaltered. The changes were, however, discrete and probably not clinically significant. On day 3, all parameters except aPTT in group 1 (not measured in group 2) indicated a continuous coagulation activity. Conclusion. The tendency for coagulation activity altered based on the length and degree of surgery. A continuously altered activity was observed compatible with the reported increased risk of venous thromboembolism at day 3. However, before introducing thromboprophylaxis guidelines larger series of multicentre studies are needed. Hindawi Publishing Corporation 2014 2014-02-26 /pmc/articles/PMC4208503/ /pubmed/25379558 http://dx.doi.org/10.1155/2014/756809 Text en Copyright © 2014 Hayarpi H. Kordjian et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kordjian, Hayarpi H. Nybo, Mads Qvist, Niels Alterations in the Coagulation System during Major Visceral Surgery in Children |
title | Alterations in the Coagulation System during Major Visceral Surgery in Children |
title_full | Alterations in the Coagulation System during Major Visceral Surgery in Children |
title_fullStr | Alterations in the Coagulation System during Major Visceral Surgery in Children |
title_full_unstemmed | Alterations in the Coagulation System during Major Visceral Surgery in Children |
title_short | Alterations in the Coagulation System during Major Visceral Surgery in Children |
title_sort | alterations in the coagulation system during major visceral surgery in children |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208503/ https://www.ncbi.nlm.nih.gov/pubmed/25379558 http://dx.doi.org/10.1155/2014/756809 |
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