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Forearm vasodilator responses to a β‐adrenergic receptor agonist in premenopausal and postmenopausal women

Beta‐adrenergic vasodilator responses may be blunted in humans who are at an increased risk for hypertension. Because menopause is associated with an increase in blood pressure, we tested the hypothesis that forearm blood flow responses to the β‐adrenergic receptor agonist isoproterenol are blunted...

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Main Authors: Harvey, Ronee E., Barnes, Jill N., Charkoudian, Nisha, Curry, Timothy B., Eisenach, John H., Hart, Emma C., Joyner, Michael J.
Format: Online Article Text
Language:English
Published: Wiley Periodicals, Inc. 2014
Subjects:
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208635/
https://www.ncbi.nlm.nih.gov/pubmed/24907296
http://dx.doi.org/10.14814/phy2.12032
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author Harvey, Ronee E.
Barnes, Jill N.
Charkoudian, Nisha
Curry, Timothy B.
Eisenach, John H.
Hart, Emma C.
Joyner, Michael J.
author_facet Harvey, Ronee E.
Barnes, Jill N.
Charkoudian, Nisha
Curry, Timothy B.
Eisenach, John H.
Hart, Emma C.
Joyner, Michael J.
author_sort Harvey, Ronee E.
collection PubMed
description Beta‐adrenergic vasodilator responses may be blunted in humans who are at an increased risk for hypertension. Because menopause is associated with an increase in blood pressure, we tested the hypothesis that forearm blood flow responses to the β‐adrenergic receptor agonist isoproterenol are blunted in older, postmenopausal women compared to young, premenopausal women. We used venous occlusion plethysmography to measure forearm blood flow in young premenopausal (26 ± 1 years; n = 13) and postmenopausal (61 ± 2 years; n = 12) women. Forearm blood flow and mean arterial pressure were measured at baseline and during isoproterenol infusion at 1.0, 3.0, 6.0, and 12.0 ng/100 mL tissue/min. The two groups did not differ in body mass index or mean arterial pressure. Baseline forearm blood flow was similar between young and postmenopausal women (3.7 ± 0.5 vs. 2.9 ± 0.4 mL/100 mL tissue/min, respectively; P > 0.05). At the lowest dose of isoproterenol, forearm blood flow vasodilator responses were lower in postmenopausal women compared with young women (5.8 ± 0.4 vs. 7.4 ± 0.3 mL/100 mL tissue/min, respectively; P < 0.05). Thereafter, forearm blood flow remained similar between the groups for the remaining isoproterenol doses. In conclusion, β‐adrenergic receptor‐mediated forearm vasodilator responses are blunted in healthy, older postmenopausal women at lower but not higher doses of isoproterenol. This suggests that in aging women, β‐adrenergic receptor‐mediated vasodilator responses may be blunted at a moderate level of stimulation while maximum receptor responses are preserved.
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spelling pubmed-42086352014-11-25 Forearm vasodilator responses to a β‐adrenergic receptor agonist in premenopausal and postmenopausal women Harvey, Ronee E. Barnes, Jill N. Charkoudian, Nisha Curry, Timothy B. Eisenach, John H. Hart, Emma C. Joyner, Michael J. Physiol Rep Original Research Beta‐adrenergic vasodilator responses may be blunted in humans who are at an increased risk for hypertension. Because menopause is associated with an increase in blood pressure, we tested the hypothesis that forearm blood flow responses to the β‐adrenergic receptor agonist isoproterenol are blunted in older, postmenopausal women compared to young, premenopausal women. We used venous occlusion plethysmography to measure forearm blood flow in young premenopausal (26 ± 1 years; n = 13) and postmenopausal (61 ± 2 years; n = 12) women. Forearm blood flow and mean arterial pressure were measured at baseline and during isoproterenol infusion at 1.0, 3.0, 6.0, and 12.0 ng/100 mL tissue/min. The two groups did not differ in body mass index or mean arterial pressure. Baseline forearm blood flow was similar between young and postmenopausal women (3.7 ± 0.5 vs. 2.9 ± 0.4 mL/100 mL tissue/min, respectively; P > 0.05). At the lowest dose of isoproterenol, forearm blood flow vasodilator responses were lower in postmenopausal women compared with young women (5.8 ± 0.4 vs. 7.4 ± 0.3 mL/100 mL tissue/min, respectively; P < 0.05). Thereafter, forearm blood flow remained similar between the groups for the remaining isoproterenol doses. In conclusion, β‐adrenergic receptor‐mediated forearm vasodilator responses are blunted in healthy, older postmenopausal women at lower but not higher doses of isoproterenol. This suggests that in aging women, β‐adrenergic receptor‐mediated vasodilator responses may be blunted at a moderate level of stimulation while maximum receptor responses are preserved. Wiley Periodicals, Inc. 2014-06-11 /pmc/articles/PMC4208635/ /pubmed/24907296 http://dx.doi.org/10.14814/phy2.12032 Text en © 2014 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Harvey, Ronee E.
Barnes, Jill N.
Charkoudian, Nisha
Curry, Timothy B.
Eisenach, John H.
Hart, Emma C.
Joyner, Michael J.
Forearm vasodilator responses to a β‐adrenergic receptor agonist in premenopausal and postmenopausal women
title Forearm vasodilator responses to a β‐adrenergic receptor agonist in premenopausal and postmenopausal women
title_full Forearm vasodilator responses to a β‐adrenergic receptor agonist in premenopausal and postmenopausal women
title_fullStr Forearm vasodilator responses to a β‐adrenergic receptor agonist in premenopausal and postmenopausal women
title_full_unstemmed Forearm vasodilator responses to a β‐adrenergic receptor agonist in premenopausal and postmenopausal women
title_short Forearm vasodilator responses to a β‐adrenergic receptor agonist in premenopausal and postmenopausal women
title_sort forearm vasodilator responses to a β‐adrenergic receptor agonist in premenopausal and postmenopausal women
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208635/
https://www.ncbi.nlm.nih.gov/pubmed/24907296
http://dx.doi.org/10.14814/phy2.12032
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