A new twist on an old idea part 2: cyclosporine preserves normal mitochondrial but not cardiomyocyte function in mini‐swine with compensated heart failure

We recently developed a clinically relevant mini‐swine model of heart failure with preserved ejection fraction (HFpEF), in which diastolic dysfunction was associated with increased mitochondrial permeability transition (MPT). Early diastolic function is ATP and Ca(2+)‐dependent, thus, we hypothesize...

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Detalles Bibliográficos
Autores principales: Hiemstra, Jessica A., Gutiérrez‐Aguilar, Manuel, Marshall, Kurt D., McCommis, Kyle S., Zgoda, Pamela J., Cruz‐Rivera, Noelany, Jenkins, Nathan T., Krenz, Maike, Domeier, Timothy L., Baines, Christopher P., Emter, Craig A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc. 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208639/
https://www.ncbi.nlm.nih.gov/pubmed/24963034
http://dx.doi.org/10.14814/phy2.12050

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