Indazole-Type Alkaloids from Nigella sativa Seeds Exhibit Antihyperglycemic Effects via AMPK Activation in Vitro

[Image: see text] Six rare naturally occurring indazole-type alkaloids including two new compounds, 17-O-(β-d-glucopyranosyl)-4-O-methylnigellidine (1) and nigelanoid (2), and four known compounds (3–6) were isolated from a defatted extract of Nigella sativa (black cumin) seeds. 17-O-(β-d-Glucopyran...

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Autores principales: Yuan, Tao, Nahar, Pragati, Sharma, Meenakshi, Liu, Ke, Slitt, Angela, Aisa, H. A., Seeram, Navindra P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208670/
https://www.ncbi.nlm.nih.gov/pubmed/25299458
http://dx.doi.org/10.1021/np500398m
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author Yuan, Tao
Nahar, Pragati
Sharma, Meenakshi
Liu, Ke
Slitt, Angela
Aisa, H. A.
Seeram, Navindra P.
author_facet Yuan, Tao
Nahar, Pragati
Sharma, Meenakshi
Liu, Ke
Slitt, Angela
Aisa, H. A.
Seeram, Navindra P.
author_sort Yuan, Tao
collection PubMed
description [Image: see text] Six rare naturally occurring indazole-type alkaloids including two new compounds, 17-O-(β-d-glucopyranosyl)-4-O-methylnigellidine (1) and nigelanoid (2), and four known compounds (3–6) were isolated from a defatted extract of Nigella sativa (black cumin) seeds. 17-O-(β-d-Glucopyranosyl)-4-O-methylnigellidine (1) increased glucose consumption by liver hepatocytes (HepG2 cells) through activation of AMP-activated protein kinase (AMPK). Also, this is the first report of compounds 4 and 6 from a natural source.
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spelling pubmed-42086702015-10-09 Indazole-Type Alkaloids from Nigella sativa Seeds Exhibit Antihyperglycemic Effects via AMPK Activation in Vitro Yuan, Tao Nahar, Pragati Sharma, Meenakshi Liu, Ke Slitt, Angela Aisa, H. A. Seeram, Navindra P. J Nat Prod [Image: see text] Six rare naturally occurring indazole-type alkaloids including two new compounds, 17-O-(β-d-glucopyranosyl)-4-O-methylnigellidine (1) and nigelanoid (2), and four known compounds (3–6) were isolated from a defatted extract of Nigella sativa (black cumin) seeds. 17-O-(β-d-Glucopyranosyl)-4-O-methylnigellidine (1) increased glucose consumption by liver hepatocytes (HepG2 cells) through activation of AMP-activated protein kinase (AMPK). Also, this is the first report of compounds 4 and 6 from a natural source. American Chemical Society and American Society of Pharmacognosy 2014-10-09 2014-10-24 /pmc/articles/PMC4208670/ /pubmed/25299458 http://dx.doi.org/10.1021/np500398m Text en Copyright © 2014 American Chemical Society and American Society of Pharmacognosy Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html)
spellingShingle Yuan, Tao
Nahar, Pragati
Sharma, Meenakshi
Liu, Ke
Slitt, Angela
Aisa, H. A.
Seeram, Navindra P.
Indazole-Type Alkaloids from Nigella sativa Seeds Exhibit Antihyperglycemic Effects via AMPK Activation in Vitro
title Indazole-Type Alkaloids from Nigella sativa Seeds Exhibit Antihyperglycemic Effects via AMPK Activation in Vitro
title_full Indazole-Type Alkaloids from Nigella sativa Seeds Exhibit Antihyperglycemic Effects via AMPK Activation in Vitro
title_fullStr Indazole-Type Alkaloids from Nigella sativa Seeds Exhibit Antihyperglycemic Effects via AMPK Activation in Vitro
title_full_unstemmed Indazole-Type Alkaloids from Nigella sativa Seeds Exhibit Antihyperglycemic Effects via AMPK Activation in Vitro
title_short Indazole-Type Alkaloids from Nigella sativa Seeds Exhibit Antihyperglycemic Effects via AMPK Activation in Vitro
title_sort indazole-type alkaloids from nigella sativa seeds exhibit antihyperglycemic effects via ampk activation in vitro
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208670/
https://www.ncbi.nlm.nih.gov/pubmed/25299458
http://dx.doi.org/10.1021/np500398m
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