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Brain structural abnormalities in behavior therapy-resistant obsessive-compulsive disorder revealed by voxel-based morphometry
BACKGROUND: Although several functional imaging studies have demonstrated that behavior therapy (BT) modifies the neural circuits involved in the pathogenesis of obsessive-compulsive disorder (OCD), the structural abnormalities underlying BT-resistant OCD remain unknown. METHODS: In this study, we e...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208702/ https://www.ncbi.nlm.nih.gov/pubmed/25349476 http://dx.doi.org/10.2147/NDT.S69652 |
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author | Hashimoto, Nobuhiko Nakaaki, Shutaro Kawaguchi, Akiko Sato, Junko Kasai, Harumasa Nakamae, Takashi Narumoto, Jin Miyata, Jun Furukawa, Toshi A Mimura, Masaru |
author_facet | Hashimoto, Nobuhiko Nakaaki, Shutaro Kawaguchi, Akiko Sato, Junko Kasai, Harumasa Nakamae, Takashi Narumoto, Jin Miyata, Jun Furukawa, Toshi A Mimura, Masaru |
author_sort | Hashimoto, Nobuhiko |
collection | PubMed |
description | BACKGROUND: Although several functional imaging studies have demonstrated that behavior therapy (BT) modifies the neural circuits involved in the pathogenesis of obsessive-compulsive disorder (OCD), the structural abnormalities underlying BT-resistant OCD remain unknown. METHODS: In this study, we examined the existence of regional structural abnormalities in both the gray matter and the white matter of patients with OCD at baseline using voxel-based morphometry in responders (n=24) and nonresponders (n=15) to subsequent BT. Three-dimensional T1-weighted magnetic resonance imaging was performed before the completion of 12 weeks of BT. RESULTS: Relative to the responders, the nonresponders exhibited significantly smaller gray matter volumes in the right ventromedial prefrontal cortex, the right orbitofrontal cortex, the right precentral gyrus, and the left anterior cingulate cortex. In addition, relative to the responders, the nonresponders exhibited significantly smaller white matter volumes in the left cingulate bundle and the left superior frontal white matter. CONCLUSION: These results suggest that the brain structures in several areas, including the orbitofrontal cortex, anterior cingulate cortex, and cingulate bundles, are related to the lack of a response to BT in patients with OCD. The use of a voxel-based morphometry approach may be advantageous to understanding differences in brain abnormalities between responders and nonresponders to BT. |
format | Online Article Text |
id | pubmed-4208702 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-42087022014-10-27 Brain structural abnormalities in behavior therapy-resistant obsessive-compulsive disorder revealed by voxel-based morphometry Hashimoto, Nobuhiko Nakaaki, Shutaro Kawaguchi, Akiko Sato, Junko Kasai, Harumasa Nakamae, Takashi Narumoto, Jin Miyata, Jun Furukawa, Toshi A Mimura, Masaru Neuropsychiatr Dis Treat Original Research BACKGROUND: Although several functional imaging studies have demonstrated that behavior therapy (BT) modifies the neural circuits involved in the pathogenesis of obsessive-compulsive disorder (OCD), the structural abnormalities underlying BT-resistant OCD remain unknown. METHODS: In this study, we examined the existence of regional structural abnormalities in both the gray matter and the white matter of patients with OCD at baseline using voxel-based morphometry in responders (n=24) and nonresponders (n=15) to subsequent BT. Three-dimensional T1-weighted magnetic resonance imaging was performed before the completion of 12 weeks of BT. RESULTS: Relative to the responders, the nonresponders exhibited significantly smaller gray matter volumes in the right ventromedial prefrontal cortex, the right orbitofrontal cortex, the right precentral gyrus, and the left anterior cingulate cortex. In addition, relative to the responders, the nonresponders exhibited significantly smaller white matter volumes in the left cingulate bundle and the left superior frontal white matter. CONCLUSION: These results suggest that the brain structures in several areas, including the orbitofrontal cortex, anterior cingulate cortex, and cingulate bundles, are related to the lack of a response to BT in patients with OCD. The use of a voxel-based morphometry approach may be advantageous to understanding differences in brain abnormalities between responders and nonresponders to BT. Dove Medical Press 2014-10-20 /pmc/articles/PMC4208702/ /pubmed/25349476 http://dx.doi.org/10.2147/NDT.S69652 Text en © 2014 Hashimoto et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Hashimoto, Nobuhiko Nakaaki, Shutaro Kawaguchi, Akiko Sato, Junko Kasai, Harumasa Nakamae, Takashi Narumoto, Jin Miyata, Jun Furukawa, Toshi A Mimura, Masaru Brain structural abnormalities in behavior therapy-resistant obsessive-compulsive disorder revealed by voxel-based morphometry |
title | Brain structural abnormalities in behavior therapy-resistant obsessive-compulsive disorder revealed by voxel-based morphometry |
title_full | Brain structural abnormalities in behavior therapy-resistant obsessive-compulsive disorder revealed by voxel-based morphometry |
title_fullStr | Brain structural abnormalities in behavior therapy-resistant obsessive-compulsive disorder revealed by voxel-based morphometry |
title_full_unstemmed | Brain structural abnormalities in behavior therapy-resistant obsessive-compulsive disorder revealed by voxel-based morphometry |
title_short | Brain structural abnormalities in behavior therapy-resistant obsessive-compulsive disorder revealed by voxel-based morphometry |
title_sort | brain structural abnormalities in behavior therapy-resistant obsessive-compulsive disorder revealed by voxel-based morphometry |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208702/ https://www.ncbi.nlm.nih.gov/pubmed/25349476 http://dx.doi.org/10.2147/NDT.S69652 |
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