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DDX3X Induces Primary EGFR-TKI Resistance Based on Intratumor Heterogeneity in Lung Cancer Cells Harboring EGFR-Activating Mutations

The specific mechanisms how lung cancer cells harboring epidermal growth factor receptor (EGFR) activating mutations can survive treatment with EGFR-tyrosine kinase inhibitors (TKIs) until they eventually acquire treatment-resistance genetic mutations are unclear. The phenotypic diversity of cancer...

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Detalles Bibliográficos
Autores principales:	Nozaki, Koichiro, Kagamu, Hiroshi, Shoji, Satoshi, Igarashi, Natsue, Ohtsubo, Aya, Okajima, Masaaki, Miura, Satoru, Watanabe, Satoshi, Yoshizawa, Hirohisa, Narita, Ichiei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208809/ https://www.ncbi.nlm.nih.gov/pubmed/25343452 http://dx.doi.org/10.1371/journal.pone.0111019

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