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Comparison of Ovulation Induction Protocols After Endometrioma Resection
BACKGROUND AND OBJECTIVES: The aim of this study was to compare the in vitro fertilization (IVF) outcomes of long gonadotropin-releasing hormone agonist (GnRH-a) and GnRH-antagonist (GnRH-ant) protocols in endometriosis patients who have undergone laparoscopic endometrioma resection surgery. To our...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society of Laparoendoscopic Surgeons
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208901/ https://www.ncbi.nlm.nih.gov/pubmed/25392665 http://dx.doi.org/10.4293/JSLS.2014.00128 |
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author | Bastu, Ercan Yasa, Cenk Dural, Ozlem Mutlu, Mehmet Firat Celik, Cem Ugurlucan, Funda Gungor Buyru, Faruk |
author_facet | Bastu, Ercan Yasa, Cenk Dural, Ozlem Mutlu, Mehmet Firat Celik, Cem Ugurlucan, Funda Gungor Buyru, Faruk |
author_sort | Bastu, Ercan |
collection | PubMed |
description | BACKGROUND AND OBJECTIVES: The aim of this study was to compare the in vitro fertilization (IVF) outcomes of long gonadotropin-releasing hormone agonist (GnRH-a) and GnRH-antagonist (GnRH-ant) protocols in endometriosis patients who have undergone laparoscopic endometrioma resection surgery. To our knowledge, there is no study in the current literature that compares the effectiveness of long GnRH-a and GnRH-ant protocols in management of IVF cycles in endometriosis patients who underwent laparoscopic endometrioma resection surgery. METHODS: Eighty-six patients with stage III to IV endometriosis who had undergone laparoscopic resection surgery for endometrioma were divided into 2 groups: those who had ovarian stimulation with a long GnRH-a protocol (n = 44), and those who had ovarian stimulation with a GnRH-ant protocol (n = 42). RESULTS: The number of follicles on human chorionic gonadotropin injection day, duration of hyperstimulation, number of retrieved metaphase II oocytes, and total number of grade 1 embryos were statically significantly higher in the long GnRH-a protocol. There were no significant differences in positive β-human chorionic gonadotropin pregnancy rates (25% vs 21.4%; P = .269) and ongoing pregnancy rates per patient (20.5% vs 19.1%; P = .302) between the 2 protocols. CONCLUSIONS: Long GnRH-a and GnRH-ant protocols both present similar IVF outcomes in patients with endometriosis who have undergone laparoscopic endometrioma resection surgery. A long GnRH-a protocol may lead to a higher number of embryos that can be cryopreserved, providing the possibility of additional embryo transfers without having to go through the process of ovarian stimulation again. |
format | Online Article Text |
id | pubmed-4208901 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Society of Laparoendoscopic Surgeons |
record_format | MEDLINE/PubMed |
spelling | pubmed-42089012014-10-27 Comparison of Ovulation Induction Protocols After Endometrioma Resection Bastu, Ercan Yasa, Cenk Dural, Ozlem Mutlu, Mehmet Firat Celik, Cem Ugurlucan, Funda Gungor Buyru, Faruk JSLS Scientific Papers BACKGROUND AND OBJECTIVES: The aim of this study was to compare the in vitro fertilization (IVF) outcomes of long gonadotropin-releasing hormone agonist (GnRH-a) and GnRH-antagonist (GnRH-ant) protocols in endometriosis patients who have undergone laparoscopic endometrioma resection surgery. To our knowledge, there is no study in the current literature that compares the effectiveness of long GnRH-a and GnRH-ant protocols in management of IVF cycles in endometriosis patients who underwent laparoscopic endometrioma resection surgery. METHODS: Eighty-six patients with stage III to IV endometriosis who had undergone laparoscopic resection surgery for endometrioma were divided into 2 groups: those who had ovarian stimulation with a long GnRH-a protocol (n = 44), and those who had ovarian stimulation with a GnRH-ant protocol (n = 42). RESULTS: The number of follicles on human chorionic gonadotropin injection day, duration of hyperstimulation, number of retrieved metaphase II oocytes, and total number of grade 1 embryos were statically significantly higher in the long GnRH-a protocol. There were no significant differences in positive β-human chorionic gonadotropin pregnancy rates (25% vs 21.4%; P = .269) and ongoing pregnancy rates per patient (20.5% vs 19.1%; P = .302) between the 2 protocols. CONCLUSIONS: Long GnRH-a and GnRH-ant protocols both present similar IVF outcomes in patients with endometriosis who have undergone laparoscopic endometrioma resection surgery. A long GnRH-a protocol may lead to a higher number of embryos that can be cryopreserved, providing the possibility of additional embryo transfers without having to go through the process of ovarian stimulation again. Society of Laparoendoscopic Surgeons 2014 /pmc/articles/PMC4208901/ /pubmed/25392665 http://dx.doi.org/10.4293/JSLS.2014.00128 Text en © 2014 by JSLS, Journal of the Society of Laparoendoscopic Surgeons. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License (http://creativecommons.org/licenses/by-nc-nd/3.0/us/), which permits for noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited and is not altered in any way. |
spellingShingle | Scientific Papers Bastu, Ercan Yasa, Cenk Dural, Ozlem Mutlu, Mehmet Firat Celik, Cem Ugurlucan, Funda Gungor Buyru, Faruk Comparison of Ovulation Induction Protocols After Endometrioma Resection |
title | Comparison of Ovulation Induction Protocols After Endometrioma Resection |
title_full | Comparison of Ovulation Induction Protocols After Endometrioma Resection |
title_fullStr | Comparison of Ovulation Induction Protocols After Endometrioma Resection |
title_full_unstemmed | Comparison of Ovulation Induction Protocols After Endometrioma Resection |
title_short | Comparison of Ovulation Induction Protocols After Endometrioma Resection |
title_sort | comparison of ovulation induction protocols after endometrioma resection |
topic | Scientific Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208901/ https://www.ncbi.nlm.nih.gov/pubmed/25392665 http://dx.doi.org/10.4293/JSLS.2014.00128 |
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