Positive Selection during the Evolution of the Blood Coagulation Factors in the Context of Their Disease-Causing Mutations

Blood coagulation occurs through a cascade of enzymes and cofactors that produces a fibrin clot, while otherwise maintaining hemostasis. The 11 human coagulation factors (FG, FII–FXIII) have been identified across all vertebrates, suggesting that they emerged with the first vertebrates around 500 Ma...

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Detalles Bibliográficos
Autores principales: Rallapalli, Pavithra M., Orengo, Christine A., Studer, Romain A., Perkins, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209140/
https://www.ncbi.nlm.nih.gov/pubmed/25158795
http://dx.doi.org/10.1093/molbev/msu248

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