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Mexiletine as a treatment for primary erythromelalgia: normalization of biophysical properties of mutant L858F Na(V)1.7 sodium channels

BACKGROUND AND PURPOSE: The non-selective sodium channel inhibitor mexiletine has been found to be effective in several animal models of chronic pain and has become popular in the clinical setting as an orally available alternative to lidocaine. It remains unclear why patients with monogenic pain di...

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Detalles Bibliográficos
Autores principales:	Cregg, R, Cox, J J, Bennett, D L H, Wood, J N, Werdehausen, R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209151/ https://www.ncbi.nlm.nih.gov/pubmed/24866741 http://dx.doi.org/10.1111/bph.12788

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