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Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly

Amyloid fibrils are self-propagating entities that spread pathology in several devastating disorders including Alzheimer's disease (AD). In AD, amyloid-β (Aβ) peptides form extracellular plaques that contribute to cognitive decline. One potential therapeutic strategy is to develop inhibitors th...

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Detalles Bibliográficos
Autores principales:	Seither, Katelyn M., McMahon, Heather A., Singh, Nikita, Wang, Hejia, Cushman-Nick, Mimi, Montalvo, Geronda L., DeGrado, William F., Shorter, James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209162/ https://www.ncbi.nlm.nih.gov/pubmed/25142005 http://dx.doi.org/10.1042/BJ20131609

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