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Gastric Invasive Micropapillary Carcinoma with Intestinal Phenotypes Harboring a TP53 R175H Mutation
We report a case of gastric invasive micropapillary carcinoma (IMPC) in an 86-year-old female patient. She was admitted to our hospital with a chief complaint of bloody emesis. Upper gastrointestinal endoscopy found a gastric adenocarcinoma at the antrum. The biopsy specimens showed moderately diffe...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209268/ https://www.ncbi.nlm.nih.gov/pubmed/25408652 http://dx.doi.org/10.1159/000367583 |
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author | Ikeda, Hideyuki Kukitsu, Takehiro Johmen, Wataru Nakamura, Hajime Yamauchi, Natumi Ishikawa, Kazuma Saikawa, Takashi Noda, Sayaka Saitoh, Tadanori Ueno, Yoshinori Noda, Yuuya Yamazaki, Sayuki Kuroda, Yoshikazu Koshiko, Susumu Sasagawa, Yutaka |
author_facet | Ikeda, Hideyuki Kukitsu, Takehiro Johmen, Wataru Nakamura, Hajime Yamauchi, Natumi Ishikawa, Kazuma Saikawa, Takashi Noda, Sayaka Saitoh, Tadanori Ueno, Yoshinori Noda, Yuuya Yamazaki, Sayuki Kuroda, Yoshikazu Koshiko, Susumu Sasagawa, Yutaka |
author_sort | Ikeda, Hideyuki |
collection | PubMed |
description | We report a case of gastric invasive micropapillary carcinoma (IMPC) in an 86-year-old female patient. She was admitted to our hospital with a chief complaint of bloody emesis. Upper gastrointestinal endoscopy found a gastric adenocarcinoma at the antrum. The biopsy specimens showed moderately differentiated adenocarcinoma with invasive small tumor nests. Distal gastrectomy with systematic lymph node dissection demonstrated that the tumor had IMPC through a pathological examination. Despite the depth of tumor invasion (the submucosa), extensive lymph node metastases were observed. Anti-D2-40 immunostaining revealed numerous infiltrating tumor cell nests in the lymphatic vessels, which could explain subsequent multiple lymph node metastases. The adenocarcinoma showed intestinal phenotypes by several immunohistochemical studies. One of these antibodies (CD10) clearly demonstrated the inverted apical-basal (inside-out) pattern of IMPC, whereas it showed an ordinary pattern in intestinal metaplasia adjacent to the tumor. Furthermore, genetic analysis by direct sequencing revealed a point mutation in the exon 5 of TP53 in the tumor. The mutation presumably harbors a missense mutation from Arg to His at the codon 175 (R175H). R175H has been previously described as a ‘gain-of-function’ mutation with a high invasive or metastatic potential in several types of cancers. In summary, this is one of the first reported cases of gastric IMPC with intestinal phenotypes harboring a TP53 R175H mutation in the literature. |
format | Online Article Text |
id | pubmed-4209268 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-42092682014-11-18 Gastric Invasive Micropapillary Carcinoma with Intestinal Phenotypes Harboring a TP53 R175H Mutation Ikeda, Hideyuki Kukitsu, Takehiro Johmen, Wataru Nakamura, Hajime Yamauchi, Natumi Ishikawa, Kazuma Saikawa, Takashi Noda, Sayaka Saitoh, Tadanori Ueno, Yoshinori Noda, Yuuya Yamazaki, Sayuki Kuroda, Yoshikazu Koshiko, Susumu Sasagawa, Yutaka Case Rep Oncol Published online: September, 2014 We report a case of gastric invasive micropapillary carcinoma (IMPC) in an 86-year-old female patient. She was admitted to our hospital with a chief complaint of bloody emesis. Upper gastrointestinal endoscopy found a gastric adenocarcinoma at the antrum. The biopsy specimens showed moderately differentiated adenocarcinoma with invasive small tumor nests. Distal gastrectomy with systematic lymph node dissection demonstrated that the tumor had IMPC through a pathological examination. Despite the depth of tumor invasion (the submucosa), extensive lymph node metastases were observed. Anti-D2-40 immunostaining revealed numerous infiltrating tumor cell nests in the lymphatic vessels, which could explain subsequent multiple lymph node metastases. The adenocarcinoma showed intestinal phenotypes by several immunohistochemical studies. One of these antibodies (CD10) clearly demonstrated the inverted apical-basal (inside-out) pattern of IMPC, whereas it showed an ordinary pattern in intestinal metaplasia adjacent to the tumor. Furthermore, genetic analysis by direct sequencing revealed a point mutation in the exon 5 of TP53 in the tumor. The mutation presumably harbors a missense mutation from Arg to His at the codon 175 (R175H). R175H has been previously described as a ‘gain-of-function’ mutation with a high invasive or metastatic potential in several types of cancers. In summary, this is one of the first reported cases of gastric IMPC with intestinal phenotypes harboring a TP53 R175H mutation in the literature. S. Karger AG 2014-09-03 /pmc/articles/PMC4209268/ /pubmed/25408652 http://dx.doi.org/10.1159/000367583 Text en Copyright © 2014 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
spellingShingle | Published online: September, 2014 Ikeda, Hideyuki Kukitsu, Takehiro Johmen, Wataru Nakamura, Hajime Yamauchi, Natumi Ishikawa, Kazuma Saikawa, Takashi Noda, Sayaka Saitoh, Tadanori Ueno, Yoshinori Noda, Yuuya Yamazaki, Sayuki Kuroda, Yoshikazu Koshiko, Susumu Sasagawa, Yutaka Gastric Invasive Micropapillary Carcinoma with Intestinal Phenotypes Harboring a TP53 R175H Mutation |
title | Gastric Invasive Micropapillary Carcinoma with Intestinal Phenotypes Harboring a TP53 R175H Mutation |
title_full | Gastric Invasive Micropapillary Carcinoma with Intestinal Phenotypes Harboring a TP53 R175H Mutation |
title_fullStr | Gastric Invasive Micropapillary Carcinoma with Intestinal Phenotypes Harboring a TP53 R175H Mutation |
title_full_unstemmed | Gastric Invasive Micropapillary Carcinoma with Intestinal Phenotypes Harboring a TP53 R175H Mutation |
title_short | Gastric Invasive Micropapillary Carcinoma with Intestinal Phenotypes Harboring a TP53 R175H Mutation |
title_sort | gastric invasive micropapillary carcinoma with intestinal phenotypes harboring a tp53 r175h mutation |
topic | Published online: September, 2014 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209268/ https://www.ncbi.nlm.nih.gov/pubmed/25408652 http://dx.doi.org/10.1159/000367583 |
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