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Dyspnea in Chronic Fatigue Syndrome (CFS): Comparison of Two Prospective Cross-Sectional Studies

Chronic Fatigue Syndrome (CFS) subjects have many systemic complaints including shortness of breath. Dyspnea was compared in two CFS and control cohorts to characterize pathophysiology. Cohort 1 of 257 CFS and 456 control subjects were compared using the Medical Research Council chronic Dyspnea Scal...

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Autores principales: Ravindran, Murugan K., Adewuyi, Oluwatoyin, Zheng, Yin, Rayhan, Rakib U., Le, Uyenphuong, Timbol, Christian R., Merck, Samantha, Esteitie, Rania, Cooney, Michelle, Read, Charles, Baraniuk, James N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Canadian Center of Science and Education 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209305/
https://www.ncbi.nlm.nih.gov/pubmed/23445698
http://dx.doi.org/10.5539/gjhs.v5n2p94
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author Ravindran, Murugan K.
Adewuyi, Oluwatoyin
Zheng, Yin
Rayhan, Rakib U.
Le, Uyenphuong
Timbol, Christian R.
Merck, Samantha
Esteitie, Rania
Cooney, Michelle
Read, Charles
Baraniuk, James N.
author_facet Ravindran, Murugan K.
Adewuyi, Oluwatoyin
Zheng, Yin
Rayhan, Rakib U.
Le, Uyenphuong
Timbol, Christian R.
Merck, Samantha
Esteitie, Rania
Cooney, Michelle
Read, Charles
Baraniuk, James N.
author_sort Ravindran, Murugan K.
collection PubMed
description Chronic Fatigue Syndrome (CFS) subjects have many systemic complaints including shortness of breath. Dyspnea was compared in two CFS and control cohorts to characterize pathophysiology. Cohort 1 of 257 CFS and 456 control subjects were compared using the Medical Research Council chronic Dyspnea Scale (MRC Score; range 0-5). Cohort 2 of 106 CFS and 90 controls answered a Dyspnea Severity Score (range 0-20) adapted from the MRC Score. Subsets of both cohorts completed CFS Severity Scores, fatigue, and other questionnaires. A subset had pulmonary function and total lung capacity measurements. Results show MRC Scores were equivalent between sexes in Cohort 1 CFS (1.92 [1.72-2.16]; mean [95% C.I.]) and controls (0.31 [0.23-0.39]; p<0.0001). Receiver-operator curves identified 2 as the threshold for positive MRC Scores in Cohort 1. This indicated 54% of CFS, but only 3% of controls, had significant dyspnea. In Cohort 2, Dyspnea Score threshold of 4 indicated shortness of breath in 67% of CFS and 23% of controls. Cohort 2 Dyspnea Scores were higher for CFS (7.80 [6.60-9.00]) than controls (2.40 [1.60-3.20]; p<0.0001). CFS had significantly worse fatigue and other complaints compared to controls. Pulmonary function was normal in CFS, but Borg scores and sensations of chest pain and dizziness were significantly greater during testing than controls. General linear model of Cohort 2 CFS responses linked Dyspnea with rapid heart rate, chest pain and dizziness. In conclusion, sensory hypersensitivity without airflow limitation contributed to dyspnea in CFS. Correlates of dyspnea in controls were distinct from CFS suggesting different mechanisms.
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spelling pubmed-42093052014-10-26 Dyspnea in Chronic Fatigue Syndrome (CFS): Comparison of Two Prospective Cross-Sectional Studies Ravindran, Murugan K. Adewuyi, Oluwatoyin Zheng, Yin Rayhan, Rakib U. Le, Uyenphuong Timbol, Christian R. Merck, Samantha Esteitie, Rania Cooney, Michelle Read, Charles Baraniuk, James N. Glob J Health Sci Articles Chronic Fatigue Syndrome (CFS) subjects have many systemic complaints including shortness of breath. Dyspnea was compared in two CFS and control cohorts to characterize pathophysiology. Cohort 1 of 257 CFS and 456 control subjects were compared using the Medical Research Council chronic Dyspnea Scale (MRC Score; range 0-5). Cohort 2 of 106 CFS and 90 controls answered a Dyspnea Severity Score (range 0-20) adapted from the MRC Score. Subsets of both cohorts completed CFS Severity Scores, fatigue, and other questionnaires. A subset had pulmonary function and total lung capacity measurements. Results show MRC Scores were equivalent between sexes in Cohort 1 CFS (1.92 [1.72-2.16]; mean [95% C.I.]) and controls (0.31 [0.23-0.39]; p<0.0001). Receiver-operator curves identified 2 as the threshold for positive MRC Scores in Cohort 1. This indicated 54% of CFS, but only 3% of controls, had significant dyspnea. In Cohort 2, Dyspnea Score threshold of 4 indicated shortness of breath in 67% of CFS and 23% of controls. Cohort 2 Dyspnea Scores were higher for CFS (7.80 [6.60-9.00]) than controls (2.40 [1.60-3.20]; p<0.0001). CFS had significantly worse fatigue and other complaints compared to controls. Pulmonary function was normal in CFS, but Borg scores and sensations of chest pain and dizziness were significantly greater during testing than controls. General linear model of Cohort 2 CFS responses linked Dyspnea with rapid heart rate, chest pain and dizziness. In conclusion, sensory hypersensitivity without airflow limitation contributed to dyspnea in CFS. Correlates of dyspnea in controls were distinct from CFS suggesting different mechanisms. Canadian Center of Science and Education 2013-03 2012-12-12 /pmc/articles/PMC4209305/ /pubmed/23445698 http://dx.doi.org/10.5539/gjhs.v5n2p94 Text en Copyright: © Canadian Center of Science and Education http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Articles
Ravindran, Murugan K.
Adewuyi, Oluwatoyin
Zheng, Yin
Rayhan, Rakib U.
Le, Uyenphuong
Timbol, Christian R.
Merck, Samantha
Esteitie, Rania
Cooney, Michelle
Read, Charles
Baraniuk, James N.
Dyspnea in Chronic Fatigue Syndrome (CFS): Comparison of Two Prospective Cross-Sectional Studies
title Dyspnea in Chronic Fatigue Syndrome (CFS): Comparison of Two Prospective Cross-Sectional Studies
title_full Dyspnea in Chronic Fatigue Syndrome (CFS): Comparison of Two Prospective Cross-Sectional Studies
title_fullStr Dyspnea in Chronic Fatigue Syndrome (CFS): Comparison of Two Prospective Cross-Sectional Studies
title_full_unstemmed Dyspnea in Chronic Fatigue Syndrome (CFS): Comparison of Two Prospective Cross-Sectional Studies
title_short Dyspnea in Chronic Fatigue Syndrome (CFS): Comparison of Two Prospective Cross-Sectional Studies
title_sort dyspnea in chronic fatigue syndrome (cfs): comparison of two prospective cross-sectional studies
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209305/
https://www.ncbi.nlm.nih.gov/pubmed/23445698
http://dx.doi.org/10.5539/gjhs.v5n2p94
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