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Altered ghrelin secretion in mice in response to diet-induced obesity and Roux-en-Y gastric bypass

The current study examined potential mechanisms for altered circulating ghrelin levels observed in diet-induced obesity (DIO) and following weight loss resulting from Roux-en-Y gastric bypass (RYGB). We hypothesized that circulating ghrelin levels were altered in obesity and after weight loss throug...

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Autores principales: Uchida, Aki, Zechner, Juliet F., Mani, Bharath K., Park, Won-mee, Aguirre, Vincent, Zigman, Jeffrey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209356/
https://www.ncbi.nlm.nih.gov/pubmed/25353000
http://dx.doi.org/10.1016/j.molmet.2014.07.009
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author Uchida, Aki
Zechner, Juliet F.
Mani, Bharath K.
Park, Won-mee
Aguirre, Vincent
Zigman, Jeffrey M.
author_facet Uchida, Aki
Zechner, Juliet F.
Mani, Bharath K.
Park, Won-mee
Aguirre, Vincent
Zigman, Jeffrey M.
author_sort Uchida, Aki
collection PubMed
description The current study examined potential mechanisms for altered circulating ghrelin levels observed in diet-induced obesity (DIO) and following weight loss resulting from Roux-en-Y gastric bypass (RYGB). We hypothesized that circulating ghrelin levels were altered in obesity and after weight loss through changes in ghrelin cell responsiveness to physiological cues. We confirmed lower ghrelin levels in DIO mice and demonstrated elevated ghrelin levels in mice 6 weeks post-RYGB. In both DIO and RYGB settings, these changes in ghrelin levels were associated with altered ghrelin cell responsiveness to two key physiological modulators of ghrelin secretion – glucose and norepinephrine. In DIO mice, increases in ghrelin cell density within both the stomach and duodenum and in somatostatin-immunoreactive D cell density in the duodenum were observed. Our findings provide new insights into the regulation of ghrelin secretion and its relation to circulating ghrelin within the contexts of obesity and weight loss.
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spelling pubmed-42093562014-10-28 Altered ghrelin secretion in mice in response to diet-induced obesity and Roux-en-Y gastric bypass Uchida, Aki Zechner, Juliet F. Mani, Bharath K. Park, Won-mee Aguirre, Vincent Zigman, Jeffrey M. Mol Metab Original Article The current study examined potential mechanisms for altered circulating ghrelin levels observed in diet-induced obesity (DIO) and following weight loss resulting from Roux-en-Y gastric bypass (RYGB). We hypothesized that circulating ghrelin levels were altered in obesity and after weight loss through changes in ghrelin cell responsiveness to physiological cues. We confirmed lower ghrelin levels in DIO mice and demonstrated elevated ghrelin levels in mice 6 weeks post-RYGB. In both DIO and RYGB settings, these changes in ghrelin levels were associated with altered ghrelin cell responsiveness to two key physiological modulators of ghrelin secretion – glucose and norepinephrine. In DIO mice, increases in ghrelin cell density within both the stomach and duodenum and in somatostatin-immunoreactive D cell density in the duodenum were observed. Our findings provide new insights into the regulation of ghrelin secretion and its relation to circulating ghrelin within the contexts of obesity and weight loss. Elsevier 2014-08-01 /pmc/articles/PMC4209356/ /pubmed/25353000 http://dx.doi.org/10.1016/j.molmet.2014.07.009 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Original Article
Uchida, Aki
Zechner, Juliet F.
Mani, Bharath K.
Park, Won-mee
Aguirre, Vincent
Zigman, Jeffrey M.
Altered ghrelin secretion in mice in response to diet-induced obesity and Roux-en-Y gastric bypass
title Altered ghrelin secretion in mice in response to diet-induced obesity and Roux-en-Y gastric bypass
title_full Altered ghrelin secretion in mice in response to diet-induced obesity and Roux-en-Y gastric bypass
title_fullStr Altered ghrelin secretion in mice in response to diet-induced obesity and Roux-en-Y gastric bypass
title_full_unstemmed Altered ghrelin secretion in mice in response to diet-induced obesity and Roux-en-Y gastric bypass
title_short Altered ghrelin secretion in mice in response to diet-induced obesity and Roux-en-Y gastric bypass
title_sort altered ghrelin secretion in mice in response to diet-induced obesity and roux-en-y gastric bypass
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209356/
https://www.ncbi.nlm.nih.gov/pubmed/25353000
http://dx.doi.org/10.1016/j.molmet.2014.07.009
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