Cargando…

Mirk kinase inhibition blocks the in vivo growth of pancreatic cancer cells

The Mirk/dyrk1B gene is upregulated and sometimes amplified in pancreatic ductal carcinomas. In poor microenvironmental conditions Mirk mediates cell survival by maintaining cancer cells in a largely quiescent, noncycling state and by decreasing toxic ROS levels through maintaining expression of a s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deng, Xiaobing, Friedman, Eileen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209603/ https://www.ncbi.nlm.nih.gov/pubmed/25352950

Ejemplares similares

Mirk kinase inhibition targets ovarian cancer ascites
por: Deng, Xiaobing, et al.
Publicado: (2014)

The Role of Mirk Kinase in Sarcomas
por: Friedman, Eileen
Publicado: (2011)

Mirk/dyrk1B kinase is upregulated following inhibition of mTOR
por: Deng, Xiaobing, et al.
Publicado: (2014)

The normal function of the cancer kinase Mirk/dyrk1B is to reduce reactive oxygen species
por: Deng, Xiaobing, et al.
Publicado: (2014)

Mirk/dyrk1B Kinase in Ovarian Cancer
por: Friedman, Eileen
Publicado: (2013)

The Kinase Mirk/dyrk1B: A Possible Therapeutic Target in Pancreatic Cancer
por: Friedman, Eileen
Publicado: (2010)

The involvement of FoxO in cell survival and chemosensitivity mediated by Mirk/Dyrk1B in ovarian cancer
por: GAO, JINGCHUN, et al.
Publicado: (2011)

Mirk/Dyrk1B mediates G0/G1 to S phase cell cycle progression and cell survival involving MAPK/ERK signaling in human cancer cells
por: Gao, Jingchun, et al.
Publicado: (2013)

Deferasirox, an oral iron chelator, with gemcitabine synergistically inhibits pancreatic cancer cell growth in vitro and in vivo
por: Shinoda, Shuhei, et al.
Publicado: (2018)

A small molecule inhibitor of atypical protein kinase C signaling inhibits pancreatic cancer cell transformed growth and invasion
por: Butler, Amanda M., et al.
Publicado: (2015)

Inhibition of pancreatic cancer cell growth in vitro by the tyrphostin group of tyrosine kinase inhibitors.
por: Gillespie, J., et al.
Publicado: (1993)

SRC family kinase (SFK) inhibition reduces rhabdomyosarcoma cell growth in vitro and in vivo and triggers p38 MAP kinase-mediated differentiation
por: Casini, Nadia, et al.
Publicado: (2015)

Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression
por: Mohammed, Altaf, et al.
Publicado: (2015)

Sulforaphane inhibits growth and blocks Wnt/β-catenin signaling of colorectal cancer cells
por: Bernkopf, Dominic B., et al.
Publicado: (2018)

Src kinase inhibition restores E-cadherin expression in dasatinib-sensitive pancreatic cancer cells
por: Dosch, Austin R., et al.
Publicado: (2019)

Daurinol blocks breast and lung cancer metastasis and development by inhibition of focal adhesion kinase (FAK)
por: Woo, Jong Kyu, et al.
Publicado: (2017)

Foretinib inhibits angiogenesis, lymphangiogenesis and tumor growth of pancreatic cancer in vivo by decreasing VEGFR-2/3 and TIE-2 signaling
por: Chen, Hsiu-Mei, et al.
Publicado: (2015)

Adiponectin receptor agonists inhibit leptin induced pSTAT3 and in vivo pancreatic tumor growth
por: Messaggio, Fanuel, et al.
Publicado: (2017)

Suppressing NRIP1 inhibits growth of breast cancer cells in vitro and in vivo
por: Aziz, Moammir H., et al.
Publicado: (2015)

Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2
por: Yue, Wen, et al.
Publicado: (2015)

A recombinant chimeric protein specifically induces mutant KRAS degradation and potently inhibits pancreatic tumor growth
por: Pan, Ting, et al.
Publicado: (2016)

Novel multiple tyrosine kinase inhibitor ponatinib inhibits bFGF-activated signaling in neuroblastoma cells and suppresses neuroblastoma growth in vivo
por: Li, Haoyu, et al.
Publicado: (2016)

IL10-modified Human Mesenchymal Stem Cells inhibit Pancreatic Cancer growth through Angiogenesis Inhibition
por: Zhao, Chunyan, et al.
Publicado: (2020)

TLR-activated plasmacytoid dendritic cells inhibit breast cancer cell growth in vitro and in vivo
por: Wu, Jing, et al.
Publicado: (2016)

Trimetazidine inhibits liver fibrosis and hepatic stellate cell proliferation and blocks transforming growth factor-β (TGFβ)/Smad signaling in vitro and in vivo
por: Ding, Wenwen, et al.
Publicado: (2022)

STAT3 down regulates LC3 to inhibit autophagy and pancreatic cancer cell growth
por: Gong, Jingjing, et al.
Publicado: (2014)

MutY-Homolog (MYH) inhibition reduces pancreatic cancer cell growth and increases chemosensitivity
por: Sharbeen, George, et al.
Publicado: (2016)

Knockdown of COPS3 Inhibits Lung Cancer Tumor Growth in Nude Mice by Blocking Cell Cycle Progression
por: Pang, Jianan, et al.
Publicado: (2017)

Inhibition of transforming growth factor-β-activated kinase-1 blocks cancer cell adhesion, invasion, and metastasis
por: Ray, D M, et al.
Publicado: (2012)

Dasatinib blocks transcriptional and promigratory responses to transforming growth factor-beta in pancreatic adenocarcinoma cells through inhibition of Smad signalling: implications for in vivo mode of action
por: Bartscht, Tobias, et al.
Publicado: (2015)

Radiosensitization by Kinase Inhibition Revealed by Phosphoproteomic Analysis of Pancreatic Cancer Cells
por: Wiechmann, Svenja, et al.
Publicado: (2020)

Reducing the serine availability complements the inhibition of the glutamine metabolism to block leukemia cell growth
por: Polet, Florence, et al.
Publicado: (2015)

Inhibition of Polo-like Kinase 1 by HMN-214 Blocks Cell Cycle Progression and Inhibits Neuroblastoma Growth
por: Chilamakuri, Rameswari, et al.
Publicado: (2022)

Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells
por: Song, Qiaoling, et al.
Publicado: (2016)

Zfra activates memory Hyal-2+ CD3− CD19− spleen cells to block cancer growth, stemness, and metastasis in vivo
por: Lee, Ming-Hui, et al.
Publicado: (2015)

SD-208, a Novel Protein Kinase D Inhibitor, Blocks Prostate Cancer Cell Proliferation and Tumor Growth In Vivo by Inducing G2/M Cell Cycle Arrest
por: Tandon, Manuj, et al.
Publicado: (2015)

CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth in vitro
por: Tsuji, Toshiya, et al.
Publicado: (2017)

Cefradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of T-LAK cell-originated protein kinase
por: Fan, Xiaoming, et al.
Publicado: (2016)

Ellagic acid inhibits the proliferation of human pancreatic carcinoma PANC-1 cells in vitro and in vivo
por: Cheng, Hao, et al.
Publicado: (2017)

Combined MEK and Pi3′-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo
por: ElMokh, Oussama, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_jce5pnf5ee8jtg9qkk7fklmahu