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Spectrum of Hemoglobin Variants in the Population of Northern Region of West Bengal: An Ethnogenetic Proposition

CONTEXT: The birth of transfusion-dependent states of hemoglobinopathies including thalassemias is preventable by population screening and genetic counseling. Magnitude is not addressed in the Northern Region of West Bengal where many ethnic variants inhabit. AIMS AND OBJECTIVES: The aim of the foll...

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Autores principales: Goswami, Bidyut Krishna, Pramanik, Raghunath, Chakrabarty, Sudipta, Pal, Partha Pratim, Banerjee, Sarama, Bandyopadhyay, Arghya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209676/
https://www.ncbi.nlm.nih.gov/pubmed/25374858
http://dx.doi.org/10.4103/2249-4863.141614
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author Goswami, Bidyut Krishna
Pramanik, Raghunath
Chakrabarty, Sudipta
Pal, Partha Pratim
Banerjee, Sarama
Bandyopadhyay, Arghya
author_facet Goswami, Bidyut Krishna
Pramanik, Raghunath
Chakrabarty, Sudipta
Pal, Partha Pratim
Banerjee, Sarama
Bandyopadhyay, Arghya
author_sort Goswami, Bidyut Krishna
collection PubMed
description CONTEXT: The birth of transfusion-dependent states of hemoglobinopathies including thalassemias is preventable by population screening and genetic counseling. Magnitude is not addressed in the Northern Region of West Bengal where many ethnic variants inhabit. AIMS AND OBJECTIVES: The aim of the following study is to find out the burden of different entities of hemoglobinopathies, their correlation with ethnicity and the “at risk” groups. SUBJECTS AND METHODS: A descriptive study was conducted from the Hematology Unit of North Bengal Medical College over 1 year on the subjects underwent screening for hemoglobinopathies for detection of abnormal hemoglobin (Hb) variants by “cation-exchange high-performance liquid chromatography” principle along with other relevant tests. STATISTICAL ANALYSIS: Data was analyzed by frequency distribution and Chi-square test assuming P value as 95% of the level of significance using the SPSS version 16 (SPSS Inc., Chicago, Illinois, U.S.A). RESULT: Abnormal Hb variant was 47.5% among 1872. Hb E trait (34.4%) was most common followed by Hb E disease (25.3%) and others. Hb E disorders (92.7%) were observed mostly among Rajbangsi population while E-β-thalassemias (40%) in the Muslims and a heterogeneous pattern noted among tribal and mongoloid. CONCLUSION: Hb E hemoglobinopathies was high among Rajbangsi and Muslims with identification of some other hemoglobinopathies involving tribal and mongoloid.
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spelling pubmed-42096762014-11-05 Spectrum of Hemoglobin Variants in the Population of Northern Region of West Bengal: An Ethnogenetic Proposition Goswami, Bidyut Krishna Pramanik, Raghunath Chakrabarty, Sudipta Pal, Partha Pratim Banerjee, Sarama Bandyopadhyay, Arghya J Family Med Prim Care Original Article CONTEXT: The birth of transfusion-dependent states of hemoglobinopathies including thalassemias is preventable by population screening and genetic counseling. Magnitude is not addressed in the Northern Region of West Bengal where many ethnic variants inhabit. AIMS AND OBJECTIVES: The aim of the following study is to find out the burden of different entities of hemoglobinopathies, their correlation with ethnicity and the “at risk” groups. SUBJECTS AND METHODS: A descriptive study was conducted from the Hematology Unit of North Bengal Medical College over 1 year on the subjects underwent screening for hemoglobinopathies for detection of abnormal hemoglobin (Hb) variants by “cation-exchange high-performance liquid chromatography” principle along with other relevant tests. STATISTICAL ANALYSIS: Data was analyzed by frequency distribution and Chi-square test assuming P value as 95% of the level of significance using the SPSS version 16 (SPSS Inc., Chicago, Illinois, U.S.A). RESULT: Abnormal Hb variant was 47.5% among 1872. Hb E trait (34.4%) was most common followed by Hb E disease (25.3%) and others. Hb E disorders (92.7%) were observed mostly among Rajbangsi population while E-β-thalassemias (40%) in the Muslims and a heterogeneous pattern noted among tribal and mongoloid. CONCLUSION: Hb E hemoglobinopathies was high among Rajbangsi and Muslims with identification of some other hemoglobinopathies involving tribal and mongoloid. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4209676/ /pubmed/25374858 http://dx.doi.org/10.4103/2249-4863.141614 Text en Copyright: © Journal of Family Medicine and Primary Care http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Goswami, Bidyut Krishna
Pramanik, Raghunath
Chakrabarty, Sudipta
Pal, Partha Pratim
Banerjee, Sarama
Bandyopadhyay, Arghya
Spectrum of Hemoglobin Variants in the Population of Northern Region of West Bengal: An Ethnogenetic Proposition
title Spectrum of Hemoglobin Variants in the Population of Northern Region of West Bengal: An Ethnogenetic Proposition
title_full Spectrum of Hemoglobin Variants in the Population of Northern Region of West Bengal: An Ethnogenetic Proposition
title_fullStr Spectrum of Hemoglobin Variants in the Population of Northern Region of West Bengal: An Ethnogenetic Proposition
title_full_unstemmed Spectrum of Hemoglobin Variants in the Population of Northern Region of West Bengal: An Ethnogenetic Proposition
title_short Spectrum of Hemoglobin Variants in the Population of Northern Region of West Bengal: An Ethnogenetic Proposition
title_sort spectrum of hemoglobin variants in the population of northern region of west bengal: an ethnogenetic proposition
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209676/
https://www.ncbi.nlm.nih.gov/pubmed/25374858
http://dx.doi.org/10.4103/2249-4863.141614
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