Low-affinity FcγR interactions can decide the fate of novel human IgG-sensitised red blood cells and platelets

G1Δnab is a mutant human IgG1 constant region with a lower ability to interact with FcγR than the natural IgG constant regions. Radiolabelled RBCs and platelets sensitised with specific G1Δnab Abs were cleared more slowly from human circulation than IgG1-sensitised counterparts. However, non-destruc...

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Detalles Bibliográficos
Autores principales: Armour, Kathryn L, Smith, Cheryl S, Turner, Craig P, Kirton, Christopher M, Wilkes, Anthony M, Hadley, Andrew G, Ghevaert, Cedric, Williamson, Lorna M, Clark, Michael R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Clinical Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209800/
https://www.ncbi.nlm.nih.gov/pubmed/24285214
http://dx.doi.org/10.1002/eji.201343825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209800/
https://www.ncbi.nlm.nih.gov/pubmed/24285214
http://dx.doi.org/10.1002/eji.201343825

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