TCR-engineered T cells: A model of inducible TCR expression to dissect the interrelationship between two TCRs

TCR gene modified T cells for adoptive therapy simultaneously express the Tg TCR and the endogenous TCR, which might lead to mispaired TCRs with harmful unknown specificity and to a reduced function of TCR-Tg T cells. We generated dual TCR T cells in two settings in which either TCR was constitutive...

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Detalles Bibliográficos
Autores principales: Reuß, Simone, Sebestyén, Zsolt, Heinz, Niels, Loew, Rainer, Baum, Christopher, Debets, Reno, Uckert, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Molecular Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209802/
https://www.ncbi.nlm.nih.gov/pubmed/24114521
http://dx.doi.org/10.1002/eji.201343591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209802/
https://www.ncbi.nlm.nih.gov/pubmed/24114521
http://dx.doi.org/10.1002/eji.201343591

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