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PI3Kγ kinase activity is required for optimal T-cell activation and differentiation
Phosphatidylinositol-3-kinase gamma (PI3Kγ) is a leukocyte-specific lipid kinase with signaling function downstream of G protein-coupled receptors to regulate cell trafficking, but its role in T cells remains unclear. To investigate the requirement of PI3Kγ kinase activity in T-cell function, we stu...
Autores principales: | Ladygina, Nadia, Gottipati, Sridevi, Ngo, Karen, Castro, Glenda, Ma, Jing-Ying, Banie, Homayon, Rao, Tadimeti S, Fung-Leung, Wai-Ping |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BlackWell Publishing Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209804/ https://www.ncbi.nlm.nih.gov/pubmed/24030559 http://dx.doi.org/10.1002/eji.201343812 |
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