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Flt3/Flt3L Participates in the Process of Regulating Dendritic Cells and Regulatory T Cells in DSS-Induced Colitis

The immunoregulation between dendritic cells (DCs) and regulatory T cells (T-regs) plays an important role in the pathogenesis of ulcerative colitis (UC). Recent research showed that Fms-like tyrosine kinase 3 (Flt3) and Flt3 ligand (Flt3L) were involved in the process of DCs regulating T-regs. The...

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Autores principales: Mao, Jing-Wei, Huang, Yu-Shuang, Tang, Hai-Ying, Bi, Jian, Liu, Yan-Fei, Wang, Ying-De
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209836/
https://www.ncbi.nlm.nih.gov/pubmed/25371672
http://dx.doi.org/10.1155/2014/483578
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author Mao, Jing-Wei
Huang, Yu-Shuang
Tang, Hai-Ying
Bi, Jian
Liu, Yan-Fei
Wang, Ying-De
author_facet Mao, Jing-Wei
Huang, Yu-Shuang
Tang, Hai-Ying
Bi, Jian
Liu, Yan-Fei
Wang, Ying-De
author_sort Mao, Jing-Wei
collection PubMed
description The immunoregulation between dendritic cells (DCs) and regulatory T cells (T-regs) plays an important role in the pathogenesis of ulcerative colitis (UC). Recent research showed that Fms-like tyrosine kinase 3 (Flt3) and Flt3 ligand (Flt3L) were involved in the process of DCs regulating T-regs. The DSS-induced colitis model is widely used because of its simplicity and many similarities with human UC. In this study, we observe the disease activity index (DAI) and histological scoring, detect the amounts of DCs and T-regs and expression of Flt3/Flt3L, and investigate Flt3/Flt3L participating in the process of DCs regulating T-regs in DSS-induced colitis. Our findings suggest that the reduction of Flt3 and Flt3L expression may possibly induce colonic immunoregulatory imbalance between CD103(+)MHCII(+)DCs and CD4(+)CD25(+)FoxP3(+)T-regs in DSS-induced colitis. Flt3/Flt3L participates in the process of regulating DCS and T-regs in the pathogenesis of UC, at least, in the acute stage of this disease.
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spelling pubmed-42098362014-11-04 Flt3/Flt3L Participates in the Process of Regulating Dendritic Cells and Regulatory T Cells in DSS-Induced Colitis Mao, Jing-Wei Huang, Yu-Shuang Tang, Hai-Ying Bi, Jian Liu, Yan-Fei Wang, Ying-De Gastroenterol Res Pract Research Article The immunoregulation between dendritic cells (DCs) and regulatory T cells (T-regs) plays an important role in the pathogenesis of ulcerative colitis (UC). Recent research showed that Fms-like tyrosine kinase 3 (Flt3) and Flt3 ligand (Flt3L) were involved in the process of DCs regulating T-regs. The DSS-induced colitis model is widely used because of its simplicity and many similarities with human UC. In this study, we observe the disease activity index (DAI) and histological scoring, detect the amounts of DCs and T-regs and expression of Flt3/Flt3L, and investigate Flt3/Flt3L participating in the process of DCs regulating T-regs in DSS-induced colitis. Our findings suggest that the reduction of Flt3 and Flt3L expression may possibly induce colonic immunoregulatory imbalance between CD103(+)MHCII(+)DCs and CD4(+)CD25(+)FoxP3(+)T-regs in DSS-induced colitis. Flt3/Flt3L participates in the process of regulating DCS and T-regs in the pathogenesis of UC, at least, in the acute stage of this disease. Hindawi Publishing Corporation 2014 2014-10-13 /pmc/articles/PMC4209836/ /pubmed/25371672 http://dx.doi.org/10.1155/2014/483578 Text en Copyright © 2014 Jing-Wei Mao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mao, Jing-Wei
Huang, Yu-Shuang
Tang, Hai-Ying
Bi, Jian
Liu, Yan-Fei
Wang, Ying-De
Flt3/Flt3L Participates in the Process of Regulating Dendritic Cells and Regulatory T Cells in DSS-Induced Colitis
title Flt3/Flt3L Participates in the Process of Regulating Dendritic Cells and Regulatory T Cells in DSS-Induced Colitis
title_full Flt3/Flt3L Participates in the Process of Regulating Dendritic Cells and Regulatory T Cells in DSS-Induced Colitis
title_fullStr Flt3/Flt3L Participates in the Process of Regulating Dendritic Cells and Regulatory T Cells in DSS-Induced Colitis
title_full_unstemmed Flt3/Flt3L Participates in the Process of Regulating Dendritic Cells and Regulatory T Cells in DSS-Induced Colitis
title_short Flt3/Flt3L Participates in the Process of Regulating Dendritic Cells and Regulatory T Cells in DSS-Induced Colitis
title_sort flt3/flt3l participates in the process of regulating dendritic cells and regulatory t cells in dss-induced colitis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209836/
https://www.ncbi.nlm.nih.gov/pubmed/25371672
http://dx.doi.org/10.1155/2014/483578
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