Regioselective Chemoenzymatic Synthesis of Ganglioside Disialyl Tetrasaccharide Epitopes

[Image: see text] A novel chemoenzymatic approach for the synthesis of disialyl tetrasaccharide epitopes found as the terminal oligosaccharides of GD1α, GT1aα, and GQ1bα is described. It relies on chemical manipulation of enzymatically generated trisaccharides as conformationally constrained accepto...

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Detalles Bibliográficos
Autores principales: Meng, Xin, Yao, Wenlong, Cheng, Jiansong, Zhang, Xu, Jin, Lan, Yu, Hai, Chen, Xi, Wang, Fengshan, Cao, Hongzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210053/
https://www.ncbi.nlm.nih.gov/pubmed/24649890
http://dx.doi.org/10.1021/ja5000609
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author Meng, Xin
Yao, Wenlong
Cheng, Jiansong
Zhang, Xu
Jin, Lan
Yu, Hai
Chen, Xi
Wang, Fengshan
Cao, Hongzhi
author_facet Meng, Xin
Yao, Wenlong
Cheng, Jiansong
Zhang, Xu
Jin, Lan
Yu, Hai
Chen, Xi
Wang, Fengshan
Cao, Hongzhi
author_sort Meng, Xin
collection PubMed
description [Image: see text] A novel chemoenzymatic approach for the synthesis of disialyl tetrasaccharide epitopes found as the terminal oligosaccharides of GD1α, GT1aα, and GQ1bα is described. It relies on chemical manipulation of enzymatically generated trisaccharides as conformationally constrained acceptors for regioselective enzymatic α2–6-sialylation. This strategy provides a new route for easy access to disialyl tetrasaccharide epitopes and their derivatives.
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spelling pubmed-42100532015-03-20 Regioselective Chemoenzymatic Synthesis of Ganglioside Disialyl Tetrasaccharide Epitopes Meng, Xin Yao, Wenlong Cheng, Jiansong Zhang, Xu Jin, Lan Yu, Hai Chen, Xi Wang, Fengshan Cao, Hongzhi J Am Chem Soc [Image: see text] A novel chemoenzymatic approach for the synthesis of disialyl tetrasaccharide epitopes found as the terminal oligosaccharides of GD1α, GT1aα, and GQ1bα is described. It relies on chemical manipulation of enzymatically generated trisaccharides as conformationally constrained acceptors for regioselective enzymatic α2–6-sialylation. This strategy provides a new route for easy access to disialyl tetrasaccharide epitopes and their derivatives. American Chemical Society 2014-03-20 2014-04-09 /pmc/articles/PMC4210053/ /pubmed/24649890 http://dx.doi.org/10.1021/ja5000609 Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html)
spellingShingle Meng, Xin
Yao, Wenlong
Cheng, Jiansong
Zhang, Xu
Jin, Lan
Yu, Hai
Chen, Xi
Wang, Fengshan
Cao, Hongzhi
Regioselective Chemoenzymatic Synthesis of Ganglioside Disialyl Tetrasaccharide Epitopes
title Regioselective Chemoenzymatic Synthesis of Ganglioside Disialyl Tetrasaccharide Epitopes
title_full Regioselective Chemoenzymatic Synthesis of Ganglioside Disialyl Tetrasaccharide Epitopes
title_fullStr Regioselective Chemoenzymatic Synthesis of Ganglioside Disialyl Tetrasaccharide Epitopes
title_full_unstemmed Regioselective Chemoenzymatic Synthesis of Ganglioside Disialyl Tetrasaccharide Epitopes
title_short Regioselective Chemoenzymatic Synthesis of Ganglioside Disialyl Tetrasaccharide Epitopes
title_sort regioselective chemoenzymatic synthesis of ganglioside disialyl tetrasaccharide epitopes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210053/
https://www.ncbi.nlm.nih.gov/pubmed/24649890
http://dx.doi.org/10.1021/ja5000609
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