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Total Synthesis of Viridicatumtoxin B and Analogues Thereof: Strategy Evolution, Structural Revision, and Biological Evaluation
[Image: see text] The details of the total synthesis of viridicatumtoxin B (1) are described. Initial synthetic strategies toward this intriguing tetracycline antibiotic resulted in the development of key alkylation and Lewis acid-mediated spirocyclization reactions to form the hindered EF spirojunc...
Autores principales: | Nicolaou, K. C., Hale, Christopher R. H., Nilewski, Christian, Ioannidou, Heraklidia A., ElMarrouni, Abdelatif, Nilewski, Lizanne G., Beabout, Kathryn, Wang, Tim T., Shamoo, Yousif |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2014
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210137/ https://www.ncbi.nlm.nih.gov/pubmed/25317739 http://dx.doi.org/10.1021/ja506472u |
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