Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics

[Image: see text] Ceftaroline, a recently approved β-lactam antibiotic for treatment of infections by methicillin-resistant Staphylococcus aureus (MRSA), is able to inhibit penicillin-binding protein 2a (PBP2a) by triggering an allosteric conformational change that leads to the opening of the active...

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Detalles Bibliográficos
Autores principales: Fishovitz, Jennifer, Rojas-Altuve, Alzoray, Otero, Lisandro H., Dawley, Matthew, Carrasco-López, Cesar, Chang, Mayland, Hermoso, Juan A., Mobashery, Shahriar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210145/
https://www.ncbi.nlm.nih.gov/pubmed/24955778
http://dx.doi.org/10.1021/ja5030657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210145/
https://www.ncbi.nlm.nih.gov/pubmed/24955778
http://dx.doi.org/10.1021/ja5030657

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