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The Association Between Urinary Phthalates and Lung Function
OBJECTIVE: To investigate the influence of phthalate exposure on lung function in the Canadian population. METHODS: We tested the association between 1-second forced expiratory volume (FEV(l)), forced vital capacity (FVC), and urinary phthalate metabolite levels in a nationally representative sample...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American College of Occupational and Environmental Medicine
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210172/ https://www.ncbi.nlm.nih.gov/pubmed/24709763 http://dx.doi.org/10.1097/JOM.0000000000000137 |
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author | Cakmak, Sabit Dales, Robert E. Hebbern, Chris Saravanabhavan, Gurusankar |
author_facet | Cakmak, Sabit Dales, Robert E. Hebbern, Chris Saravanabhavan, Gurusankar |
author_sort | Cakmak, Sabit |
collection | PubMed |
description | OBJECTIVE: To investigate the influence of phthalate exposure on lung function in the Canadian population. METHODS: We tested the association between 1-second forced expiratory volume (FEV(l)), forced vital capacity (FVC), and urinary phthalate metabolite levels in a nationally representative sample of 3147, from 6 to 49 years old. RESULTS: An interquartile increase in mono-n-butyl phthalate was associated with decreases in percent predicted FEV(1) of 0.8% (95% confidence interval = 0.3 to 1.4) and in FVC of 0.9% (95% confidence interval = 0.3 to 1.5). Results were similar for mono-3-carboxypropyl phthalate, mono-benzyl phthalate, and di(2-ethylhexyl) phthalate metabolites, but significant effects of the latter were only seen in males and those at least 17 years old. CONCLUSIONS: These results provide evidence that phthalate exposure may adversely affect lung function in the Canadian population. Given that these chemicals are ubiquitous, the population health burden may be significant if the associations were causal. |
format | Online Article Text |
id | pubmed-4210172 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | American College of Occupational and Environmental Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-42101722014-10-28 The Association Between Urinary Phthalates and Lung Function Cakmak, Sabit Dales, Robert E. Hebbern, Chris Saravanabhavan, Gurusankar J Occup Environ Med Original Articles OBJECTIVE: To investigate the influence of phthalate exposure on lung function in the Canadian population. METHODS: We tested the association between 1-second forced expiratory volume (FEV(l)), forced vital capacity (FVC), and urinary phthalate metabolite levels in a nationally representative sample of 3147, from 6 to 49 years old. RESULTS: An interquartile increase in mono-n-butyl phthalate was associated with decreases in percent predicted FEV(1) of 0.8% (95% confidence interval = 0.3 to 1.4) and in FVC of 0.9% (95% confidence interval = 0.3 to 1.5). Results were similar for mono-3-carboxypropyl phthalate, mono-benzyl phthalate, and di(2-ethylhexyl) phthalate metabolites, but significant effects of the latter were only seen in males and those at least 17 years old. CONCLUSIONS: These results provide evidence that phthalate exposure may adversely affect lung function in the Canadian population. Given that these chemicals are ubiquitous, the population health burden may be significant if the associations were causal. American College of Occupational and Environmental Medicine 2014-04 2014-04-08 /pmc/articles/PMC4210172/ /pubmed/24709763 http://dx.doi.org/10.1097/JOM.0000000000000137 Text en © 2014 by American College of Occupational and Environmental Medicine This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. |
spellingShingle | Original Articles Cakmak, Sabit Dales, Robert E. Hebbern, Chris Saravanabhavan, Gurusankar The Association Between Urinary Phthalates and Lung Function |
title | The Association Between Urinary Phthalates and Lung Function |
title_full | The Association Between Urinary Phthalates and Lung Function |
title_fullStr | The Association Between Urinary Phthalates and Lung Function |
title_full_unstemmed | The Association Between Urinary Phthalates and Lung Function |
title_short | The Association Between Urinary Phthalates and Lung Function |
title_sort | association between urinary phthalates and lung function |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210172/ https://www.ncbi.nlm.nih.gov/pubmed/24709763 http://dx.doi.org/10.1097/JOM.0000000000000137 |
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