Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation

Integrin-mediated force application induces a conformational change in latent TGF-β1 that leads to the release of the active form of the growth factor from the extracellular matrix (ECM). Mechanical activation of TGF-β1 is currently understood as an acute process that depends on the contractile forc...

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Detalles Bibliográficos
Autores principales: Klingberg, Franco, Chow, Melissa L., Koehler, Anne, Boo, Stellar, Buscemi, Lara, Quinn, Thomas M., Costell, Mercedes, Alman, Benjamin A., Genot, Elisabeth, Hinz, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210443/
https://www.ncbi.nlm.nih.gov/pubmed/25332161
http://dx.doi.org/10.1083/jcb.201402006

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