Role of protein kinase R in the killing of Leishmania major by macrophages in response to neutrophil elastase and TLR4 via TNFα and IFNβ

In cutaneous leishmaniasis, Leishmania amazonensis activates macrophage double-stranded, RNA-activated protein kinase R (PKR) to promote parasite growth. In our study, Leishmania major grew normally in RAW cells, RAW-expressing dominant-negative PKR (PKR-DN) cells, and macrophages of PKR-knockout mi...

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Detalles Bibliográficos
Autores principales: Faria, Marilia S., Calegari-Silva, Tereza C., de Carvalho Vivarini, Aislan, Mottram, Jeremy C., Lopes, Ulisses Gazos, Lima, Ana Paula C. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2014
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210457/
https://www.ncbi.nlm.nih.gov/pubmed/24732131
http://dx.doi.org/10.1096/fj.13-245126

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