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Polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study
BACKGROUND: Chronic kidney disease (CKD) is known to be one of the causes of cardiovascular disease and end-stage renal disease. Among the several treatable risk factors of CKD, that of dyslipidemia is relatively controversial. To clarify the association of polymorphisms in genes involved in lipid m...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210508/ https://www.ncbi.nlm.nih.gov/pubmed/25311932 http://dx.doi.org/10.1186/1476-511X-13-162 |
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author | Hishida, Asahi Wakai, Kenji Naito, Mariko Suma, Shino Sasakabe, Tae Hamajima, Nobuyuki Hosono, Satoyo Horita, Mikako Turin, Tanvir Chowdhury Suzuki, Sadao Kairupan, Tara Sefanya Mikami, Haruo Ohnaka, Keizo Watanabe, Isao Uemura, Hirokazu Kubo, Michiaki Tanaka, Hideo |
author_facet | Hishida, Asahi Wakai, Kenji Naito, Mariko Suma, Shino Sasakabe, Tae Hamajima, Nobuyuki Hosono, Satoyo Horita, Mikako Turin, Tanvir Chowdhury Suzuki, Sadao Kairupan, Tara Sefanya Mikami, Haruo Ohnaka, Keizo Watanabe, Isao Uemura, Hirokazu Kubo, Michiaki Tanaka, Hideo |
author_sort | Hishida, Asahi |
collection | PubMed |
description | BACKGROUND: Chronic kidney disease (CKD) is known to be one of the causes of cardiovascular disease and end-stage renal disease. Among the several treatable risk factors of CKD, that of dyslipidemia is relatively controversial. To clarify the association of polymorphisms in genes involved in lipid metabolism with the risk of CKD in the Japanese population, we used cross-sectional data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. METHODS: A total of 3,268 men and women, aged 35–69 years, were selected from J-MICC Study participants for inclusion in this study. Twenty-eight candidate single nucleotide polymorphisms (SNPs) were selected in 17 genes associated with the risk of lipid metabolism disorders, and genotyping of the subjects was conducted using the multiplex PCR-based invader assay. The prevalence of CKD was determined for stages 3–5 (defined as estimated glomerular filtration rate <60 ml/min/1.73 m(2)). RESULTS: Logistic regression analysis revealed that SNPs APOA5 T − 1131C (rs662799), APOA5 T1259C (rs2266788), TOMM40 A/G (rs157580), and CETP TaqIB (rs708272) were significantly associated with CKD risk in those individuals genotyped, with age- and sex-adjusted odds ratios (ORs) per minor allele (and 95% confidence intervals (CIs)) of OR 1.22 (95% CI: 1.06–1.39), 1.19 (1.03–1.37), 1.27 (1.12–1.45), and 0.81 (0.71–0.92), respectively. Analysis of the gene–environment interaction revealed that body mass index (BMI) was a significant effect modifier for APOA5 T − 1131C (rs662799) and a marginally significant effect modifier for APOA5 T/C (rs2266788), with the interaction between BMI ≥30 and individuals with at least one minor allele of each genotype of OR 10.43 (95% CI: 1.29–84.19) and 3.36 (0.87–13.01), respectively. CONCLUSIONS: Four polymorphisms in APOA5, TOMM40, and CETP were shown to be significantly associated with CKD risk, and a significant interaction between the two APOA5 SNPs and BMI on CKD risk was also demonstrated. This suggests the future possibility of personalized risk estimation for this life-limiting disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1476-511X-13-162) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4210508 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-42105082014-10-29 Polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study Hishida, Asahi Wakai, Kenji Naito, Mariko Suma, Shino Sasakabe, Tae Hamajima, Nobuyuki Hosono, Satoyo Horita, Mikako Turin, Tanvir Chowdhury Suzuki, Sadao Kairupan, Tara Sefanya Mikami, Haruo Ohnaka, Keizo Watanabe, Isao Uemura, Hirokazu Kubo, Michiaki Tanaka, Hideo Lipids Health Dis Research BACKGROUND: Chronic kidney disease (CKD) is known to be one of the causes of cardiovascular disease and end-stage renal disease. Among the several treatable risk factors of CKD, that of dyslipidemia is relatively controversial. To clarify the association of polymorphisms in genes involved in lipid metabolism with the risk of CKD in the Japanese population, we used cross-sectional data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. METHODS: A total of 3,268 men and women, aged 35–69 years, were selected from J-MICC Study participants for inclusion in this study. Twenty-eight candidate single nucleotide polymorphisms (SNPs) were selected in 17 genes associated with the risk of lipid metabolism disorders, and genotyping of the subjects was conducted using the multiplex PCR-based invader assay. The prevalence of CKD was determined for stages 3–5 (defined as estimated glomerular filtration rate <60 ml/min/1.73 m(2)). RESULTS: Logistic regression analysis revealed that SNPs APOA5 T − 1131C (rs662799), APOA5 T1259C (rs2266788), TOMM40 A/G (rs157580), and CETP TaqIB (rs708272) were significantly associated with CKD risk in those individuals genotyped, with age- and sex-adjusted odds ratios (ORs) per minor allele (and 95% confidence intervals (CIs)) of OR 1.22 (95% CI: 1.06–1.39), 1.19 (1.03–1.37), 1.27 (1.12–1.45), and 0.81 (0.71–0.92), respectively. Analysis of the gene–environment interaction revealed that body mass index (BMI) was a significant effect modifier for APOA5 T − 1131C (rs662799) and a marginally significant effect modifier for APOA5 T/C (rs2266788), with the interaction between BMI ≥30 and individuals with at least one minor allele of each genotype of OR 10.43 (95% CI: 1.29–84.19) and 3.36 (0.87–13.01), respectively. CONCLUSIONS: Four polymorphisms in APOA5, TOMM40, and CETP were shown to be significantly associated with CKD risk, and a significant interaction between the two APOA5 SNPs and BMI on CKD risk was also demonstrated. This suggests the future possibility of personalized risk estimation for this life-limiting disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1476-511X-13-162) contains supplementary material, which is available to authorized users. BioMed Central 2014-10-14 /pmc/articles/PMC4210508/ /pubmed/25311932 http://dx.doi.org/10.1186/1476-511X-13-162 Text en © Hishida et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Hishida, Asahi Wakai, Kenji Naito, Mariko Suma, Shino Sasakabe, Tae Hamajima, Nobuyuki Hosono, Satoyo Horita, Mikako Turin, Tanvir Chowdhury Suzuki, Sadao Kairupan, Tara Sefanya Mikami, Haruo Ohnaka, Keizo Watanabe, Isao Uemura, Hirokazu Kubo, Michiaki Tanaka, Hideo Polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study |
title | Polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study |
title_full | Polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study |
title_fullStr | Polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study |
title_full_unstemmed | Polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study |
title_short | Polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study |
title_sort | polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in japanese - cross-sectional data from the j-micc study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210508/ https://www.ncbi.nlm.nih.gov/pubmed/25311932 http://dx.doi.org/10.1186/1476-511X-13-162 |
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