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Racial differences in mantle cell lymphoma in the United States

BACKGROUND: MCL (mantle cell lymphoma) is a rare subtype of NHL (non-Hodgkin lymphoma) with mostly poor prognosis. Different races have different etiology, presentation, and progression patterns. METHODS: Data were analyzed on MCL patients in the United States reported to the SEER (Surveillance, Epi...

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Autores principales: Wang, Yu, Ma, Shuangge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210548/
https://www.ncbi.nlm.nih.gov/pubmed/25315847
http://dx.doi.org/10.1186/1471-2407-14-764
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author Wang, Yu
Ma, Shuangge
author_facet Wang, Yu
Ma, Shuangge
author_sort Wang, Yu
collection PubMed
description BACKGROUND: MCL (mantle cell lymphoma) is a rare subtype of NHL (non-Hodgkin lymphoma) with mostly poor prognosis. Different races have different etiology, presentation, and progression patterns. METHODS: Data were analyzed on MCL patients in the United States reported to the SEER (Surveillance, Epidemiology, and End Results) database between 1992 and 2009. SEER contains the most comprehensive population-based cancer information in the U.S., covering approximately 28% of the population. Racial groups analyzed included non-Hispanic whites, Hispanic whites, blacks, and Asians/PIs (Pacific Islanders). Patient characteristics, age-adjusted incidence rate, and survival rate were compared across races. Stratification by age, gender, and stage at diagnosis was considered. Multivariate analysis was conducted on survival. RESULTS: In the analysis of patients’ characteristics, distributions of gender, marital status, age at diagnosis, stage, and extranodal involvement were significantly different across races. For all three age groups and both male and female, non-Hispanic whites have the highest incidence rates. In the analysis of survival, for cancers diagnosed in the period of 1992–2004, no significant racial difference is observed. For cancers diagnosed in the period of 1999–2004, significant racial differences exist for the 40–64 age group and stage III and IV cancers. CONCLUSIONS: Racial differences exist among MCL patients in the U.S. in terms of patients’ characteristics, incidence, and survival. More extended data collection and analysis are needed to more comprehensively describe and understand the racial differences. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1471-2407-14-764) contains supplementary material, which is available to authorized users.
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spelling pubmed-42105482014-10-29 Racial differences in mantle cell lymphoma in the United States Wang, Yu Ma, Shuangge BMC Cancer Research Article BACKGROUND: MCL (mantle cell lymphoma) is a rare subtype of NHL (non-Hodgkin lymphoma) with mostly poor prognosis. Different races have different etiology, presentation, and progression patterns. METHODS: Data were analyzed on MCL patients in the United States reported to the SEER (Surveillance, Epidemiology, and End Results) database between 1992 and 2009. SEER contains the most comprehensive population-based cancer information in the U.S., covering approximately 28% of the population. Racial groups analyzed included non-Hispanic whites, Hispanic whites, blacks, and Asians/PIs (Pacific Islanders). Patient characteristics, age-adjusted incidence rate, and survival rate were compared across races. Stratification by age, gender, and stage at diagnosis was considered. Multivariate analysis was conducted on survival. RESULTS: In the analysis of patients’ characteristics, distributions of gender, marital status, age at diagnosis, stage, and extranodal involvement were significantly different across races. For all three age groups and both male and female, non-Hispanic whites have the highest incidence rates. In the analysis of survival, for cancers diagnosed in the period of 1992–2004, no significant racial difference is observed. For cancers diagnosed in the period of 1999–2004, significant racial differences exist for the 40–64 age group and stage III and IV cancers. CONCLUSIONS: Racial differences exist among MCL patients in the U.S. in terms of patients’ characteristics, incidence, and survival. More extended data collection and analysis are needed to more comprehensively describe and understand the racial differences. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1471-2407-14-764) contains supplementary material, which is available to authorized users. BioMed Central 2014-10-15 /pmc/articles/PMC4210548/ /pubmed/25315847 http://dx.doi.org/10.1186/1471-2407-14-764 Text en © Wang and Ma; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Wang, Yu
Ma, Shuangge
Racial differences in mantle cell lymphoma in the United States
title Racial differences in mantle cell lymphoma in the United States
title_full Racial differences in mantle cell lymphoma in the United States
title_fullStr Racial differences in mantle cell lymphoma in the United States
title_full_unstemmed Racial differences in mantle cell lymphoma in the United States
title_short Racial differences in mantle cell lymphoma in the United States
title_sort racial differences in mantle cell lymphoma in the united states
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210548/
https://www.ncbi.nlm.nih.gov/pubmed/25315847
http://dx.doi.org/10.1186/1471-2407-14-764
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