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Stability profiling of anti-malarial drug piperaquine phosphate and impurities by HPLC-UV, TOF-MS, ESI-MS and NMR

BACKGROUND: Piperaquine, 1,3-bis-[4-(7-chloroquinolyl-4)-piperazinyl-1]-propane, is an anti-malarial compound belonging to the 4-aminoquinolines, which has received renewed interest in treatment of drug resistant falciparum malaria in artemisinin-based combination therapy with dihydroartemisinin. Th...

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Detalles Bibliográficos
Autores principales:	Yan, Fang, Liu, Jie, Zeng, Xuefang, Zhang, Yuan, Hang, Taijun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210591/ https://www.ncbi.nlm.nih.gov/pubmed/25311421 http://dx.doi.org/10.1186/1475-2875-13-401

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