The cardiac muscle duplex as a method to study myocardial heterogeneity

This paper reviews the development and application of paired muscle preparations, called duplex, for the investigation of mechanisms and consequences of intra-myocardial electro-mechanical heterogeneity. We illustrate the utility of the underlying combined experimental and computational approach for...

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Detalles Bibliográficos
Autores principales: Solovyova, O., Katsnelson, L.B., Konovalov, P.V., Kursanov, A.G., Vikulova, N.A., Kohl, P., Markhasin, V.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210666/
https://www.ncbi.nlm.nih.gov/pubmed/25106702
http://dx.doi.org/10.1016/j.pbiomolbio.2014.07.010
Descripción
Sumario:This paper reviews the development and application of paired muscle preparations, called duplex, for the investigation of mechanisms and consequences of intra-myocardial electro-mechanical heterogeneity. We illustrate the utility of the underlying combined experimental and computational approach for conceptual development and integration of basic science insight with clinically relevant settings, using previously published and new data. Directions for further study are identified.

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