Genetic Polymorphisms in VIR Genes among Indian Plasmodium vivax Populations

The vir genes are antigenic genes and are considered to be possible vaccine targets. Since India is highly endemic to Plasmodium vivax, we sequenced 5 different vir genes and investigated DNA sequence variations in 93 single-clonal P. vivax isolates. High variability was observed in all the 5 vir ge...

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Autores principales: Gupta, Purva, Pande, Veena, Das, Aparup, Singh, Vineeta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Parasitology and Tropical Medicine 2014
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210742/
https://www.ncbi.nlm.nih.gov/pubmed/25352708
http://dx.doi.org/10.3347/kjp.2014.52.5.557
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author Gupta, Purva
Pande, Veena
Das, Aparup
Singh, Vineeta
author_facet Gupta, Purva
Pande, Veena
Das, Aparup
Singh, Vineeta
author_sort Gupta, Purva
collection PubMed
description The vir genes are antigenic genes and are considered to be possible vaccine targets. Since India is highly endemic to Plasmodium vivax, we sequenced 5 different vir genes and investigated DNA sequence variations in 93 single-clonal P. vivax isolates. High variability was observed in all the 5 vir genes; the vir 1/9 gene was highly diverged across Indian populations. The patterns of genetic diversity do not follow geographical locations, as geographically distant populations were found to be genetically similar. The results in general present complex genetic diversity patterns in India, requiring further in-depth population genetic and functional studies.
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spelling pubmed-42107422014-10-28 Genetic Polymorphisms in VIR Genes among Indian Plasmodium vivax Populations Gupta, Purva Pande, Veena Das, Aparup Singh, Vineeta Korean J Parasitol Brief Communication The vir genes are antigenic genes and are considered to be possible vaccine targets. Since India is highly endemic to Plasmodium vivax, we sequenced 5 different vir genes and investigated DNA sequence variations in 93 single-clonal P. vivax isolates. High variability was observed in all the 5 vir genes; the vir 1/9 gene was highly diverged across Indian populations. The patterns of genetic diversity do not follow geographical locations, as geographically distant populations were found to be genetically similar. The results in general present complex genetic diversity patterns in India, requiring further in-depth population genetic and functional studies. The Korean Society for Parasitology and Tropical Medicine 2014-10 2014-10-22 /pmc/articles/PMC4210742/ /pubmed/25352708 http://dx.doi.org/10.3347/kjp.2014.52.5.557 Text en © 2014, Korean Society for Parasitology and Tropical Medicine http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Gupta, Purva
Pande, Veena
Das, Aparup
Singh, Vineeta
Genetic Polymorphisms in VIR Genes among Indian Plasmodium vivax Populations
title Genetic Polymorphisms in VIR Genes among Indian Plasmodium vivax Populations
title_full Genetic Polymorphisms in VIR Genes among Indian Plasmodium vivax Populations
title_fullStr Genetic Polymorphisms in VIR Genes among Indian Plasmodium vivax Populations
title_full_unstemmed Genetic Polymorphisms in VIR Genes among Indian Plasmodium vivax Populations
title_short Genetic Polymorphisms in VIR Genes among Indian Plasmodium vivax Populations
title_sort genetic polymorphisms in vir genes among indian plasmodium vivax populations
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210742/
https://www.ncbi.nlm.nih.gov/pubmed/25352708
http://dx.doi.org/10.3347/kjp.2014.52.5.557
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