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Closing in on a mechanism for activation
When insulin-like growth factor-1 (IGF1) binds to its receptor, a physical constraint is released that allows the two transmembrane helices to come together to facilitate activation of the receptor.
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210822/ https://www.ncbi.nlm.nih.gov/pubmed/25350976 http://dx.doi.org/10.7554/eLife.04909 |
| _version_ | 1782341452130418688 |
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| author | Hubbard, Stevan R Miller, W Todd |
| author_facet | Hubbard, Stevan R Miller, W Todd |
| author_sort | Hubbard, Stevan R |
| collection | PubMed |
| description | When insulin-like growth factor-1 (IGF1) binds to its receptor, a physical constraint is released that allows the two transmembrane helices to come together to facilitate activation of the receptor. |
| format | Online Article Text |
| id | pubmed-4210822 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | eLife Sciences Publications, Ltd |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-42108222014-11-21 Closing in on a mechanism for activation Hubbard, Stevan R Miller, W Todd eLife Biochemistry When insulin-like growth factor-1 (IGF1) binds to its receptor, a physical constraint is released that allows the two transmembrane helices to come together to facilitate activation of the receptor. eLife Sciences Publications, Ltd 2014-10-28 /pmc/articles/PMC4210822/ /pubmed/25350976 http://dx.doi.org/10.7554/eLife.04909 Text en Copyright © 2014, Hubbard and Miller http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
| spellingShingle | Biochemistry Hubbard, Stevan R Miller, W Todd Closing in on a mechanism for activation |
| title | Closing in on a mechanism for activation |
| title_full | Closing in on a mechanism for activation |
| title_fullStr | Closing in on a mechanism for activation |
| title_full_unstemmed | Closing in on a mechanism for activation |
| title_short | Closing in on a mechanism for activation |
| title_sort | closing in on a mechanism for activation |
| topic | Biochemistry |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210822/ https://www.ncbi.nlm.nih.gov/pubmed/25350976 http://dx.doi.org/10.7554/eLife.04909 |
| work_keys_str_mv | AT hubbardstevanr closinginonamechanismforactivation AT millerwtodd closinginonamechanismforactivation |