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Modification of Marine Natural Product Ningalin B and SAR Study Lead to Potent P-Glycoprotein Inhibitors

In this study, new marine ningalin B analogues containing a piperazine or a benzoloxy group at ring C have been synthesized and evaluated on their P-gp modulating activity in human breast cancer and leukemia cell lines. Their structure-activity relationship was preliminarily studied. Compounds 19 an...

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Detalles Bibliográficos
Autores principales:	Yang, Chao, Wong, Iris L. K., Jin, Wen Bin, Jiang, Tao, Chow, Larry M. C., Wan, Sheng Biao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210895/ https://www.ncbi.nlm.nih.gov/pubmed/25329704 http://dx.doi.org/10.3390/md12105209

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