Sinulolides A–H, New Cyclopentenone and Butenolide Derivatives from Soft Coral Sinularia sp.

Eight new compounds, sinulolides A–H (1–8), along with two known compounds, α-methoxy-2,3-dimethyl-butenolide (9) and sinularone D (10), were isolated from the soft coral Sinularia sp. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis. The absolute co...

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Detalles Bibliográficos
Autores principales: Yang, Bin, Wei, Xiaoyi, Huang, Jingxia, Lin, Xiuping, Liu, Juan, Liao, Shengrong, Wang, Junfeng, Zhou, Xuefeng, Wang, Lishu, Liu, Yonghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210901/
https://www.ncbi.nlm.nih.gov/pubmed/25342460
http://dx.doi.org/10.3390/md12105316
Descripción
Sumario:Eight new compounds, sinulolides A–H (1–8), along with two known compounds, α-methoxy-2,3-dimethyl-butenolide (9) and sinularone D (10), were isolated from the soft coral Sinularia sp. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations were determined on the basis of electronic circular dichroism (ECD) data analysis. Compounds 5 and 10 exhibited moderate effects for the inhibition of NF-κB activation.

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