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Nutrients Intake Is Associated with DNA Methylation of Candidate Inflammatory Genes in a Population of Obese Subjects
The aim of the present study was to evaluate the potential association between dietary nutrients and alterations in DNA methylation in a set of five candidate genes, including CD14, Et-1, iNOS, HERV-w and TNFα, in a population of overweight/obese subjects. We evaluated possible associations between...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210937/ https://www.ncbi.nlm.nih.gov/pubmed/25340371 http://dx.doi.org/10.3390/nu6104625 |
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author | Bollati, Valentina Favero, Chiara Albetti, Benedetta Tarantini, Letizia Moroni, Alice Byun, Hyang-Min Motta, Valeria Conti, Diana Misaela Tirelli, Amedea Silvia Vigna, Luisella Bertazzi, Pier Alberto Pesatori, Angela Cecilia |
author_facet | Bollati, Valentina Favero, Chiara Albetti, Benedetta Tarantini, Letizia Moroni, Alice Byun, Hyang-Min Motta, Valeria Conti, Diana Misaela Tirelli, Amedea Silvia Vigna, Luisella Bertazzi, Pier Alberto Pesatori, Angela Cecilia |
author_sort | Bollati, Valentina |
collection | PubMed |
description | The aim of the present study was to evaluate the potential association between dietary nutrients and alterations in DNA methylation in a set of five candidate genes, including CD14, Et-1, iNOS, HERV-w and TNFα, in a population of overweight/obese subjects. We evaluated possible associations between gene methylation and clinical blood parameters, including total cholesterol (TC), low- and high-density lipoprotein cholesterol (LDL-C and HDL-C), triglyceride and homocysteine levels. We employed validated methods to assess anthropometric, clinical and dietary data, as well as pyrosequencing to evaluate DNA methylation of the five candidate genes in 165 overweight/obese subjects. There was no association between body mass index and DNA methylation of the five candidate genes in this group of subjects. Positive associations were observed between TNFα methylation and blood levels of LDL-C (β = 0.447, p = 0.002), TC/HDL-C (β = 0.467, p = 0.001) and LDL-C/HDL-C (β = 0.445, p = 0.002), as well as between HERV-w methylation and dietary intakes of β-carotene (β = 0.088, p = 0.051) and carotenoids (β = 0.083, p = 0.029). TNFα methylation showed negative associations with dietary intakes of cholesterol (β = −0.278, p = 0.048), folic acid (β = −0.339, p = 0.012), β-carotene (β = −0.332, p = 0.045), carotenoids (β = −0.331, p = 0.015) and retinol (β = −0.360, p = 0.008). These results suggest a complex relationship among nutrient intake, oxidative stress and DNA methylation. |
format | Online Article Text |
id | pubmed-4210937 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-42109372014-10-28 Nutrients Intake Is Associated with DNA Methylation of Candidate Inflammatory Genes in a Population of Obese Subjects Bollati, Valentina Favero, Chiara Albetti, Benedetta Tarantini, Letizia Moroni, Alice Byun, Hyang-Min Motta, Valeria Conti, Diana Misaela Tirelli, Amedea Silvia Vigna, Luisella Bertazzi, Pier Alberto Pesatori, Angela Cecilia Nutrients Article The aim of the present study was to evaluate the potential association between dietary nutrients and alterations in DNA methylation in a set of five candidate genes, including CD14, Et-1, iNOS, HERV-w and TNFα, in a population of overweight/obese subjects. We evaluated possible associations between gene methylation and clinical blood parameters, including total cholesterol (TC), low- and high-density lipoprotein cholesterol (LDL-C and HDL-C), triglyceride and homocysteine levels. We employed validated methods to assess anthropometric, clinical and dietary data, as well as pyrosequencing to evaluate DNA methylation of the five candidate genes in 165 overweight/obese subjects. There was no association between body mass index and DNA methylation of the five candidate genes in this group of subjects. Positive associations were observed between TNFα methylation and blood levels of LDL-C (β = 0.447, p = 0.002), TC/HDL-C (β = 0.467, p = 0.001) and LDL-C/HDL-C (β = 0.445, p = 0.002), as well as between HERV-w methylation and dietary intakes of β-carotene (β = 0.088, p = 0.051) and carotenoids (β = 0.083, p = 0.029). TNFα methylation showed negative associations with dietary intakes of cholesterol (β = −0.278, p = 0.048), folic acid (β = −0.339, p = 0.012), β-carotene (β = −0.332, p = 0.045), carotenoids (β = −0.331, p = 0.015) and retinol (β = −0.360, p = 0.008). These results suggest a complex relationship among nutrient intake, oxidative stress and DNA methylation. MDPI 2014-10-22 /pmc/articles/PMC4210937/ /pubmed/25340371 http://dx.doi.org/10.3390/nu6104625 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bollati, Valentina Favero, Chiara Albetti, Benedetta Tarantini, Letizia Moroni, Alice Byun, Hyang-Min Motta, Valeria Conti, Diana Misaela Tirelli, Amedea Silvia Vigna, Luisella Bertazzi, Pier Alberto Pesatori, Angela Cecilia Nutrients Intake Is Associated with DNA Methylation of Candidate Inflammatory Genes in a Population of Obese Subjects |
title | Nutrients Intake Is Associated with DNA Methylation of Candidate Inflammatory Genes in a Population of Obese Subjects |
title_full | Nutrients Intake Is Associated with DNA Methylation of Candidate Inflammatory Genes in a Population of Obese Subjects |
title_fullStr | Nutrients Intake Is Associated with DNA Methylation of Candidate Inflammatory Genes in a Population of Obese Subjects |
title_full_unstemmed | Nutrients Intake Is Associated with DNA Methylation of Candidate Inflammatory Genes in a Population of Obese Subjects |
title_short | Nutrients Intake Is Associated with DNA Methylation of Candidate Inflammatory Genes in a Population of Obese Subjects |
title_sort | nutrients intake is associated with dna methylation of candidate inflammatory genes in a population of obese subjects |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210937/ https://www.ncbi.nlm.nih.gov/pubmed/25340371 http://dx.doi.org/10.3390/nu6104625 |
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