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Are Delta-Aminolevulinate Dehydratase Inhibition and Metal Concentrations Additional Factors for the Age-Related Cognitive Decline?
Aging is often accompanied by cognitive impairments and influenced by oxidative status and chemical imbalances. Thus, this study was conducted to examine whether age-related cognitive deficit is associated with oxidative damage, especially with inhibition of the enzyme delta-aminolevulinate dehydrat...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211010/ https://www.ncbi.nlm.nih.gov/pubmed/25329536 http://dx.doi.org/10.3390/ijerph111010851 |
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author | Baierle, Marília Charão, Mariele F. Göethel, Gabriela Barth, Anelise Fracasso, Rafael Bubols, Guilherme Sauer, Elisa Campanharo, Sarah C. Rocha, Rafael C. C. Saint’Pierre, Tatiana D. Bordignon, Suelen Zibetti, Murilo Trentini, Clarissa M. Ávila, Daiana S. Gioda, Adriana Garcia, Solange C. |
author_facet | Baierle, Marília Charão, Mariele F. Göethel, Gabriela Barth, Anelise Fracasso, Rafael Bubols, Guilherme Sauer, Elisa Campanharo, Sarah C. Rocha, Rafael C. C. Saint’Pierre, Tatiana D. Bordignon, Suelen Zibetti, Murilo Trentini, Clarissa M. Ávila, Daiana S. Gioda, Adriana Garcia, Solange C. |
author_sort | Baierle, Marília |
collection | PubMed |
description | Aging is often accompanied by cognitive impairments and influenced by oxidative status and chemical imbalances. Thus, this study was conducted to examine whether age-related cognitive deficit is associated with oxidative damage, especially with inhibition of the enzyme delta-aminolevulinate dehydratase (ALA-D), as well as to verify the influence of some metals in the enzyme activity and cognitive performance. Blood ALA-D activity, essential (Fe, Zn, Cu, Se) and non-essential metals (Pb, Cd, Hg, As, Cr, Ni, V) were measured in 50 elderly and 20 healthy young subjects. Cognitive function was assessed by tests from Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) battery and other. The elderly group presented decreased ALA-D activity compared to the young group. The index of ALA-D reactivation was similar to both study groups, but negatively associated with metals. The mean levels of essential metals were within the reference values, while the most toxic metals were above them in both groups. Cognitive function impairments were observed in elderly group and were associated with decreased ALA-D activity, with lower levels of Se and higher levels of toxic metals (Hg and V). Results suggest that the reduced ALA-D activity in elderly can be an additional factor involved in cognitive decline, since its inhibition throughout life could lead to accumulation of the neurotoxic compound ALA. Toxic metals were found to contribute to cognitive decline and also to influence ALA-D reactivation. |
format | Online Article Text |
id | pubmed-4211010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-42110102014-10-28 Are Delta-Aminolevulinate Dehydratase Inhibition and Metal Concentrations Additional Factors for the Age-Related Cognitive Decline? Baierle, Marília Charão, Mariele F. Göethel, Gabriela Barth, Anelise Fracasso, Rafael Bubols, Guilherme Sauer, Elisa Campanharo, Sarah C. Rocha, Rafael C. C. Saint’Pierre, Tatiana D. Bordignon, Suelen Zibetti, Murilo Trentini, Clarissa M. Ávila, Daiana S. Gioda, Adriana Garcia, Solange C. Int J Environ Res Public Health Article Aging is often accompanied by cognitive impairments and influenced by oxidative status and chemical imbalances. Thus, this study was conducted to examine whether age-related cognitive deficit is associated with oxidative damage, especially with inhibition of the enzyme delta-aminolevulinate dehydratase (ALA-D), as well as to verify the influence of some metals in the enzyme activity and cognitive performance. Blood ALA-D activity, essential (Fe, Zn, Cu, Se) and non-essential metals (Pb, Cd, Hg, As, Cr, Ni, V) were measured in 50 elderly and 20 healthy young subjects. Cognitive function was assessed by tests from Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) battery and other. The elderly group presented decreased ALA-D activity compared to the young group. The index of ALA-D reactivation was similar to both study groups, but negatively associated with metals. The mean levels of essential metals were within the reference values, while the most toxic metals were above them in both groups. Cognitive function impairments were observed in elderly group and were associated with decreased ALA-D activity, with lower levels of Se and higher levels of toxic metals (Hg and V). Results suggest that the reduced ALA-D activity in elderly can be an additional factor involved in cognitive decline, since its inhibition throughout life could lead to accumulation of the neurotoxic compound ALA. Toxic metals were found to contribute to cognitive decline and also to influence ALA-D reactivation. MDPI 2014-10-17 2014-10 /pmc/articles/PMC4211010/ /pubmed/25329536 http://dx.doi.org/10.3390/ijerph111010851 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Baierle, Marília Charão, Mariele F. Göethel, Gabriela Barth, Anelise Fracasso, Rafael Bubols, Guilherme Sauer, Elisa Campanharo, Sarah C. Rocha, Rafael C. C. Saint’Pierre, Tatiana D. Bordignon, Suelen Zibetti, Murilo Trentini, Clarissa M. Ávila, Daiana S. Gioda, Adriana Garcia, Solange C. Are Delta-Aminolevulinate Dehydratase Inhibition and Metal Concentrations Additional Factors for the Age-Related Cognitive Decline? |
title | Are Delta-Aminolevulinate Dehydratase Inhibition and Metal Concentrations Additional Factors for the Age-Related Cognitive Decline? |
title_full | Are Delta-Aminolevulinate Dehydratase Inhibition and Metal Concentrations Additional Factors for the Age-Related Cognitive Decline? |
title_fullStr | Are Delta-Aminolevulinate Dehydratase Inhibition and Metal Concentrations Additional Factors for the Age-Related Cognitive Decline? |
title_full_unstemmed | Are Delta-Aminolevulinate Dehydratase Inhibition and Metal Concentrations Additional Factors for the Age-Related Cognitive Decline? |
title_short | Are Delta-Aminolevulinate Dehydratase Inhibition and Metal Concentrations Additional Factors for the Age-Related Cognitive Decline? |
title_sort | are delta-aminolevulinate dehydratase inhibition and metal concentrations additional factors for the age-related cognitive decline? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211010/ https://www.ncbi.nlm.nih.gov/pubmed/25329536 http://dx.doi.org/10.3390/ijerph111010851 |
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