Cargando…

Ghrelin Therapy Improves Survival after Whole-Body Ionizing Irradiation or Combined with Burn or Wound: Amelioration of Leukocytopenia, Thrombocytopenia, Splenomegaly, and Bone Marrow Injury

Exposure to ionizing radiation alone (RI) or combined with traumatic tissue injury (CI) is a crucial life-threatening factor in nuclear and radiological events. In our laboratory, mice exposed to (60)Co-γ-photon radiation (9.5 Gy, 0.4 Gy/min, bilateral) followed by 15% total-body-surface-area skin w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kiang, Juliann G., Zhai, Min, Liao, Pei-Jyun, Elliott, Thomas B., Gorbunov, Nikolai V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211157/ https://www.ncbi.nlm.nih.gov/pubmed/25374650 http://dx.doi.org/10.1155/2014/215858

Ejemplares similares

Pegylated G-CSF Inhibits Blood Cell Depletion, Increases Platelets, Blocks Splenomegaly, and Improves Survival after Whole-Body Ionizing Irradiation but Not after Irradiation Combined with Burn
por: Kiang, Juliann G., et al.
Publicado: (2014)

Ghrelin Therapy Decreases Incidents of Intracranial Hemorrhage in Mice after Whole-Body Ionizing Irradiation Combined with Burn Trauma
por: Gorbunov, Nikolai V., et al.
Publicado: (2017)

Bone Marrow Mesenchymal Stem Cells Increase Survival after Ionizing Irradiation Combined with Wound Trauma: Characterization and Therapy
por: Kiang, Juliann G, et al.
Publicado: (2014)

Thrombopoietin Receptor Agonist Mitigates Hematopoietic Radiation Syndrome and Improves Survival after Whole-Body Ionizing Irradiation Followed by Wound Trauma
por: Kiang, Juliann G., et al.
Publicado: (2017)

Ciprofloxacin Modulates Cytokine/Chemokine Profile in Serum, Improves Bone Marrow Repopulation, and Limits Apoptosis and Autophagy in Ileum after Whole Body Ionizing Irradiation Combined with Skin-Wound Trauma
por: Fukumoto, Risaku, et al.
Publicado: (2013)

Hemorrhage Exacerbates Radiation Effects on Survival, Leukocytopenia, Thrombopenia, Erythropenia, Bone Marrow Cell Depletion and Hematopoiesis, and Inflammation-Associated microRNAs Expression in Kidney
por: Kiang, Juliann G., et al.
Publicado: (2015)

Ghrelin therapy mitigates bone marrow injury and splenocytopenia by sustaining circulating G-CSF and KC increases after irradiation combined with wound
por: Kiang, Juliann G., et al.
Publicado: (2018)

The Evolutionary History and Spatiotemporal Dynamics of the Fever, Thrombocytopenia and Leukocytopenia Syndrome Virus (FTLSV) in China
por: Huang, Xueyong, et al.
Publicado: (2014)

A review of the impact on the ecosystem after ionizing irradiation wildlife population
por: Cannon, Georgetta, et al.
Publicado: (2022)

Cellulitis with Leukocytopenia as an Initial Sign of Acute Promyelocytic Leukemia
por: Sakamoto, Sachiko, et al.
Publicado: (2012)

Transient leukocytopenia following combination therapy for COVID-19
por: Tsuchiya, Kazuo, et al.
Publicado: (2022)

Thrombocytopenia and splenomegaly: an unusual presentation of congenital hepatic fibrosis
por: Poala, Serena Botto, et al.
Publicado: (2010)

Nephrotic Syndrome with Thrombocytopenia, Lymphadenopathy, Systemic Inflammation, and Splenomegaly
por: Nakamori, Aya, et al.
Publicado: (2017)

Predicting the probability of Gaucher disease in subjects with splenomegaly and thrombocytopenia
por: Motta, Irene, et al.
Publicado: (2021)

Autophagy and mitochondrial remodelling in mouse mesenchymal stromal cells challenged with Staphylococcus epidermidis
por: Gorbunov, Nikolai V, et al.
Publicado: (2015)

Co-Therapy of Pegylated G-CSF and Ghrelin for Enhancing Survival After Exposure to Lethal Radiation
por: Kiang, Juliann G., et al.
Publicado: (2021)

SYNERGISM OF THYMUS AND BONE MARROW IN THE PRODUCTION OF GRAFT-VERSUS-HOST SPLENOMEGALY IN X-IRRADIATED HOSTS
por: Hilgard, Henry R.
Publicado: (1970)

Multifocal Sclerosing Angiomatoid Nodular Transformation of the Spleen With Splenomegaly and Thrombocytopenia
por: He, Chendong, et al.
Publicado: (2022)

Adaptive Redox Response of Mesenchymal Stromal Cells to Stimulation with Lipopolysaccharide Inflammagen: Mechanisms of Remodeling of Tissue Barriers in Sepsis
por: Gorbunov, Nikolai V., et al.
Publicado: (2013)

EXPERIMENTAL STUDY OF CHEMOTHERAPY RELATED LEUKOCYTOPENIA TREATED BY VARIOUS PEROAL LEUCOCYTE INCREASING DRUGS
por: Xiping, Zhang, et al.
Publicado: (2016)

Abnormal DNA methylation patterns in patients with infection-caused leukocytopenia based on methylation microarrays
por: Wu, Chao, et al.
Publicado: (2020)

A novel therapy, using Ghrelin with pegylated G-CSF, inhibits brain hemorrhage from ionizing radiation or combined radiation injury
por: Kiang, JG, et al.
Publicado: (2019)

Wound trauma alters ionizing radiation dose assessment
por: Kiang, Juliann G, et al.
Publicado: (2012)

Palliative splenic irradiation for symptomatic splenomegaly in non-Hodgkin lymphoma
por: Oliveira, Liliana Castro, et al.
Publicado: (2018)

A Case of Special Complication following a Large Amount of Polyacrylamide Hydrogel Injected into the Epicranial Aponeurosis: Leukocytopenia
por: Rong, Li, et al.
Publicado: (2015)

Radioprotective effects of oral 17-dimethylaminoethylamino-17-demethoxygeldanamycin in mice: bone marrow and small intestine
por: Lu, Xinyue, et al.
Publicado: (2013)

Ghrelin, a novel therapy, corrects cytokine and NF-κB-AKT-MAPK network and mitigates intestinal injury induced by combined radiation and skin-wound trauma
por: Kiang, Juliann G., et al.
Publicado: (2020)

Ghrelin receptor controls obesity by fat burning
por: Sun, Yuxiang
Publicado: (2015)

Thrombocytopenia with multiple splenic lesions - histiocytic sarcoma of the spleen without splenomegaly: A case report
por: Huang, Kai, et al.
Publicado: (2020)

Association of thrombocytopenia with splenomegaly in malaria patients in East Kalimantan: A cross-sectional, retrospective study
por: Siagian, Loly R.D., et al.
Publicado: (2019)

Splenectomy for Splenomegaly
por: Nixon, J. A.
Publicado: (1913)

Splenomegaly in Britain
por: McNee, J. W.
Publicado: (1929)

Splenomegaly in Britain
por: McNee, J. W.
Publicado: (1929)

Lymphadenopathy and Splenomegaly
por: Lanzkowsky, Philip
Publicado: (2011)

Splenectomy for Splenomegaly
Publicado: (1914)

Primary splenic histiocytic sarcoma complicated with prolonged idiopathic thrombocytopenia and secondary bone marrow involvement: a unique surgical case presenting with splenomegaly but non-nodular lesions
por: Yamada, Sohsuke, et al.
Publicado: (2012)

Primary Splenic Diffuse Large B-Cell Lymphoma: A Rare Case of Massive Splenomegaly and Thrombocytopenia
por: Khalid, Sidra, et al.
Publicado: (2018)

Silencing of microRNA-21 in vivo ameliorates autoimmune splenomegaly in lupus mice
por: Garchow, Barry G, et al.
Publicado: (2011)

Ciprofloxacin Enhances Stress Erythropoiesis in Spleen and Increases Survival after Whole-Body Irradiation Combined with Skin-Wound Trauma
por: Fukumoto, Risaku, et al.
Publicado: (2014)

THE HUMAN SPLEEN AS AN HÆMATOPLASTIC ORGAN, AS EXEMPLIFIED IN A CASE OF SPLENOMEGALY WITH SCLEROSIS OF THE BONE-MARROW
por: Donhauser, J. L.
Publicado: (1908)

Cannot write session to /tmp/vufind_sessions/sess_fg8e0eu0g4fe5nle9o5iv2rt1g