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Analysis of silver stained nucleolar organizing regions in odontogenic cysts and tumors
OBJECTIVE: The present study aimed to investigate the probable differences in cell proliferation index of odontogenic cysts and tumors by means of a comparative silver stained nucleolar organizing region (AgNOR) quantification. STUDY DESIGN: This descriptive cross-sectional study was done on archiva...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211237/ https://www.ncbi.nlm.nih.gov/pubmed/25364178 http://dx.doi.org/10.4103/0973-029X.141345 |
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author | Prasanna, MD Charan, CR Reddy Ealla, Kranti Kiran Surekha, V Kulkarni, Ganesh Gokavarapu, Sandhya |
author_facet | Prasanna, MD Charan, CR Reddy Ealla, Kranti Kiran Surekha, V Kulkarni, Ganesh Gokavarapu, Sandhya |
author_sort | Prasanna, MD |
collection | PubMed |
description | OBJECTIVE: The present study aimed to investigate the probable differences in cell proliferation index of odontogenic cysts and tumors by means of a comparative silver stained nucleolar organizing region (AgNOR) quantification. STUDY DESIGN: This descriptive cross-sectional study was done on archival paraffin blocks (n = 62), consisting of 10 odontogenic keratocysts, 10 dentigerous cysts, 10 radicular cysts, 10 conventional ameloblastomas, 10 adenomatoid odontogenic tumors, 10 calcifying epithelial odontogenic tumors and 2 ameloblasic carcinomas. RESULTS: The mean AgNOR count of odontogenic cysts was 1.709 and the benign odontogenic tumors was 1.862. Highest AgNOR count was recorded in odontogenic keratocyst and lowest was seen in radicular cyst. Statistically significant difference in AgNOR counts of ameloblastoma and adenomatoid odontogenic tumor, amelobalastoma and calcifying epithelial odontogenic tumor, benign odontogenic tumors and ameloblastic carcinoma were seen. AgNORs in ameloblastic carcinoma were more in number and more widely spread. CONCLUSION: AgNOR technique may be considered a good indicator of cell proliferation in odontogenic cysts and tumors. |
format | Online Article Text |
id | pubmed-4211237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-42112372014-10-31 Analysis of silver stained nucleolar organizing regions in odontogenic cysts and tumors Prasanna, MD Charan, CR Reddy Ealla, Kranti Kiran Surekha, V Kulkarni, Ganesh Gokavarapu, Sandhya J Oral Maxillofac Pathol Original Article OBJECTIVE: The present study aimed to investigate the probable differences in cell proliferation index of odontogenic cysts and tumors by means of a comparative silver stained nucleolar organizing region (AgNOR) quantification. STUDY DESIGN: This descriptive cross-sectional study was done on archival paraffin blocks (n = 62), consisting of 10 odontogenic keratocysts, 10 dentigerous cysts, 10 radicular cysts, 10 conventional ameloblastomas, 10 adenomatoid odontogenic tumors, 10 calcifying epithelial odontogenic tumors and 2 ameloblasic carcinomas. RESULTS: The mean AgNOR count of odontogenic cysts was 1.709 and the benign odontogenic tumors was 1.862. Highest AgNOR count was recorded in odontogenic keratocyst and lowest was seen in radicular cyst. Statistically significant difference in AgNOR counts of ameloblastoma and adenomatoid odontogenic tumor, amelobalastoma and calcifying epithelial odontogenic tumor, benign odontogenic tumors and ameloblastic carcinoma were seen. AgNORs in ameloblastic carcinoma were more in number and more widely spread. CONCLUSION: AgNOR technique may be considered a good indicator of cell proliferation in odontogenic cysts and tumors. Medknow Publications & Media Pvt Ltd 2014-09 /pmc/articles/PMC4211237/ /pubmed/25364178 http://dx.doi.org/10.4103/0973-029X.141345 Text en Copyright: © Journal of Oral and Maxillofacial Pathology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Prasanna, MD Charan, CR Reddy Ealla, Kranti Kiran Surekha, V Kulkarni, Ganesh Gokavarapu, Sandhya Analysis of silver stained nucleolar organizing regions in odontogenic cysts and tumors |
title | Analysis of silver stained nucleolar organizing regions in odontogenic cysts and tumors |
title_full | Analysis of silver stained nucleolar organizing regions in odontogenic cysts and tumors |
title_fullStr | Analysis of silver stained nucleolar organizing regions in odontogenic cysts and tumors |
title_full_unstemmed | Analysis of silver stained nucleolar organizing regions in odontogenic cysts and tumors |
title_short | Analysis of silver stained nucleolar organizing regions in odontogenic cysts and tumors |
title_sort | analysis of silver stained nucleolar organizing regions in odontogenic cysts and tumors |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211237/ https://www.ncbi.nlm.nih.gov/pubmed/25364178 http://dx.doi.org/10.4103/0973-029X.141345 |
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