Model-Based Exposure–Response Analysis of Apixaban to Quantify Bleeding Risk in Special Populations of Subjects Undergoing Orthopedic Surgery

Population pharmacokinetic (PK) and exposure–response analyses of apixaban were performed using data from phase I–III studies to predict bleeding risks for patients receiving apixaban 2.5 mg b.i.d. after total knee or hip replacement (TKR, THR) surgery (N = 5,510). Renal function, age, gender, and b...

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Detalles Bibliográficos
Autores principales: Leil, T A, Frost, C, Wang, X, Pfister, M, LaCreta, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211262/
https://www.ncbi.nlm.nih.gov/pubmed/25229619
http://dx.doi.org/10.1038/psp.2014.34

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211262/
https://www.ncbi.nlm.nih.gov/pubmed/25229619
http://dx.doi.org/10.1038/psp.2014.34

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